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Effect of hydrophobic nanoparticle cores on the characteristics of poly(?-caprolactone)-co-d-?-tocopheryl polyethylene glycol 1000 succinate nanoparticles loaded with camptothecin |
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| รหัสดีโอไอ | |
| Creator | 1. Y. Sirithananchai 2. VB. Junyaprasert 3. K. Sakchaisri 4. J. Suksiriworapong |
| Title | Effect of hydrophobic nanoparticle cores on the characteristics of poly(?-caprolactone)-co-d-?-tocopheryl polyethylene glycol 1000 succinate nanoparticles loaded with camptothecin |
| Publisher | Faculty of Pharmacy, Mahidol University |
| Publication Year | 2558 |
| Journal Title | Mahidol University Journal of Pharmaceutical Sciences |
| Journal Vol. | 42 |
| Journal No. | 4 |
| Page no. | 169-177 |
| Keyword | Camptothecin,Poly(?-caprolactone),d-?-Tocopheryl polyethylene glycol 1000 succinate,Nanoparticles,Hydrophobic |
| Abstract | The clinical efficacy of camptothecin (CPT), a potent antitumor drug, is restricted by its insolubility in aqueous and organic solvents and its instability in physiological fluid. The incorporation of drug in nanoparticles can minimize these problems. Since CPT exhibits hydrophobic properties, the nanoparticle core with different hydrophobicity may affect the characteristics of nanoparticles. This study aimed to investigate the effect of hydrophobicity of the nanoparticle core on the characteristics of poly(?-caprolactone)-co-d-?-tocopheryl polyethylene glycol 1000 succinate (PCL-TPGS) nanoparticles for the entrapment of CPT. The result found that the increasing hydrophobicity of the nanoparticle core significantly enlarged the particle size of blank nanoparticles from 40 nm to 164 nm while it decreased the polydispersity index (PdI) from 0.518 to 0.242 and the zeta potential (ZP) from -1.79 mV to -22.9 mV. |
