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Effect of formulations on in vitro skin permeation of some metals from mineral clays |
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| รหัสดีโอไอ | |
| Creator | 1. A. Priprem 2. L. Wankao |
| Title | Effect of formulations on in vitro skin permeation of some metals from mineral clays |
| Publisher | Faculty of Pharmacy, Mahidol University |
| Publication Year | 2558 |
| Journal Title | Mahidol University Journal of Pharmaceutical Sciences |
| Journal Vol. | 42 |
| Journal No. | 1 |
| Page no. | 39-46 |
| Keyword | mineral clay,in vitro skin permeation,Mg2+,Mn2+,Zn2+,Cu2+ |
| Abstract | Mineral clay from the evaporites of the Cretaceous to early Tertiary Maha Sarakham Formation in some regions of the Northeast of Thailand containing Cu2+, Mg2+, Mn2+ and Zn2+, in various mineral forms, was used for external applications. Samples of mineral clay were collected in Udonthani and pulverized by heat to obtain plain clay (particle sizes of < 75 ?m) and then maturated to obtain mature clay. Two gel formulas, a polymer gel (formula 1) and a mineral gel (formula 2), were prepared to incorporate plain clay. In vitro skin permeation of Cu2+, Mg2+, Mn2+ and Zn2+ from plain clay, mature clay and plain clay in formula 1 or formula 2 through full-thickness skin of newborn pigs (n =6) were compared by using Franz diffusion cells and analyzed by atomic absorption spectroscopy. Trace amounts of these metals were detected in the receptor fluid. Maturation of clay with smaller size significantly enhanced skin permeation of Cu2+ (p = 0.04), Mn2+ (p = 0.04) and Zn2+ (p = 0.01). |
