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Effects of vitamin D deficient diet on microtubule-associated protein 2 expression in brains of newborn mice |
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| รหัสดีโอไอ | |
| Creator | Wei Feng |
| Title | Effects of vitamin D deficient diet on microtubule-associated protein 2 expression in brains of newborn mice |
| Contributor | Jiawen Huo, Hongyun Shi, Qingpeng Hu, Yuanlu Huang |
| Publisher | Maejo University |
| Publication Year | 2567 |
| Journal Title | Maejo International Journal of Science and Technology |
| Journal Vol. | 18 |
| Journal No. | 1 |
| Page no. | 115 |
| Keyword | vitamin D deficiency, microtubule-related protein, brains of newborn mice |
| Website title | Maejo International Journal of Science and Technology |
| ISSN | 1905-7873 |
| Abstract | Functioning as a neuroactive steroid hormone, vitamin D assumes a pivotal role in brain development, function and dynamic equilibrium. Inadequate vitamin D levels can lead to diminished expression of genes related to the growth and apoptosis of mouse brain cells. This deficiency extends to the next generation. Microtubule-associated protein 2 (MAP2), closely linked to neural cell differentiation and migration, acts as a neural cell-specific marker. It is expressed in both the neuronal cytoplasm and dendrites, serving as a substrate for the majority of protein kinases and phosphatases found in neurons. Our study findings unveil a reduction in MAP2 expression in the brains of newborn mice from pregnant mice with a diet deficient in vitamin D. Vitamin D deficiency status thus serves as a potential molecular indicator for diagnosing and prognosticating mental developmental disorders, opening avenues for novel therapeutic strategies. |
