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Acute effects of barakol and serotonergic drugs on exploratory behaviour in rats |
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| รหัสดีโอไอ | |
| Creator | Somrudee Saiyudthong, Watchareewan Thongsaard, Charles A. Marsden |
| Title | Acute effects of barakol and serotonergic drugs on exploratory behaviour in rats |
| Publisher | Faculty of Medicine,Srinakharinwirot University |
| Publication Year | 2548 |
| Journal Title | Journal of Medicine and Health Sciences |
| Journal Vol. | 12 |
| Journal No. | 3 |
| Page no. | 76-84 |
| Keyword | barakol, holeboard, exploration, receptors, serotonin |
| ISSN | 0859-3312 |
| Abstract | Barakol (10 mg/kg, i.p.), an active ingredient extracted from Cassia siamea, has been shown to have anxiolytic properties on the elevated plus-maze at a low dose similar to diazepam and to increase exploratory and locomotor behaviour. Drugs increasing serotonergic function also alter exploratory activity. The mechanism underlying the effects of barakol on exploratory behaviour has not been studied, therefore, the aim of the present study was to investigate exploratory activity in rats treated with barakol compared with drugs known to have specific action on the 5HT system. Exploratory behaviours were monitored in the rat using the holeboard model. The results show that the 5HT1A receptor agonist 8-OH-DPAT (1 mg/kg, i.p.) significantly |
