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Bridging therapeutic gaps in upper respiratory tract infections: the potential of silver nanoparticles in modern topical formulations |
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| รหัสดีโอไอ | |
| Creator | Prayuth Poowaruttanawiwit |
| Title | Bridging therapeutic gaps in upper respiratory tract infections: the potential of silver nanoparticles in modern topical formulations |
| Contributor | Teerawat Nitichaikulvattana, Punyawee Boonthanomwong, Niratcha Chaisomboon |
| Publisher | The Pharmacological and Therapeutic Society of Thailand |
| Publication Year | 2568 |
| Journal Title | Journal of Basic and Applied Pharmacology |
| Journal Vol. | 5 |
| Journal No. | 1 |
| Page no. | R1-11 |
| Keyword | silver nanoparticles, upper respiratory tract infections, antimicrobial efficacy, nasal microemulsions, topical drug delivery |
| URL Website | https://li01.tci-thaijo.org/index.php/JBAP |
| Website title | เว็บไซต์คลังข้อมูล |
| ISSN | 2774-0854 (Online) |
| Abstract | Upper respiratory tract infections (URTIs) remain a significant health issue, with current treatments limited to symptom management and antibiotics for bacterial cases. No approved topical treatments exist for prevention and treatment across pathogens. Silver nanoparticles (AgNPs) are promising due to their broad-spectrum antimicrobial properties, disrupting microbial cells and essential functions. This review evaluates the efficacy, safety, and potential of AgNP-based topical treatments like nasal sprays and microemulsions, which offer localized action, reduced side effects, and improved adherence. While nasal sprays provide convenience, microemulsions enhance bioavailability through sustained release. However, large-scale trials are needed to validate their safety and effectiveness. Unlike existing reviews, this work focuses specifically on topical applications, comparing different delivery systems and highlighting their respective advantages. The review outlines key pharmacological insights and proposes research directions for developing targeted, effective URTI therapies. |
