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Effect of red blood cell transfusion on hemoglobin (Hb) analysis of Beta0-Thalassemia/HbE disease and homozygous HbE |
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| รหัสดีโอไอ | |
| Creator | Sakorn Pornprasert |
| Title | Effect of red blood cell transfusion on hemoglobin (Hb) analysis of Beta0-Thalassemia/HbE disease and homozygous HbE |
| Publisher | Faculty of Associated Medical Sciences, Chiang Mai University |
| Publication Year | 2560 |
| Journal Title | Journal of Associated Medical Sciences |
| Journal Vol. | 50 |
| Journal No. | 1 |
| Page no. | 22-26 |
| Keyword | Blood transfusion, Beta0-thalassemia, HbE, misinterpretation |
| ISSN | 25396056 |
| Abstract | Red blood cell (RBC) transfusion is a medical therapy in patients with severe thalassemia and he?moglobinopathy. However, it also affects the hemoglobin (Hb) analysis. We report here the presentation of HbA peak on capillary electrophoresis (CE) electrophoregrams of Beta0-thalassemia/HbE and homozygous HbE patients who received RBC transfusions. The misinterpretations of Beta+-thalassemia/HbE and heterozygous HbE, respectively, were occurred. Therefore, to avoid misdiagnosis, hemoglobin analysis should be determined prior to or after 3 months of blood transfusion. When hemoglobin typing is needed within the 3 month period mentioned, history of transfusion is required to accompany the diagnosis. Moreover, molecular analysis for identification of thalassemia genotype should be performed. |
