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Extensively-drug resistant tuberculosis: A new strain and future challenge |
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| รหัสดีโอไอ | |
| Creator | 1. Ratikorn Gamngoen 2. Chanyanuch Putim 3. Bordin Burt-Indr |
| Title | Extensively-drug resistant tuberculosis: A new strain and future challenge |
| Publisher | Faculty of Associated Medical Sciences, Chiang Mai University |
| Publication Year | 2558 |
| Journal Title | Journal of Associated Medical Sciences |
| Journal Vol. | 48 |
| Journal No. | 1 |
| Page no. | 18-28 |
| Keyword | Mycobacterium tuberculosis, multi-drug resistant tuberculosis, extensively-drug resistant tuberculosis, drug-susceptibility testing, anti-tuberculosis drug |
| ISSN | 1255347 |
| Abstract | Extensively-Drug Resistant Tuberculosis (XDR-TB) is emerging as an even more ominous treat. XDR-TBis defined as TB that is resistant to any fluoroquinolone, and at least one of three injectable second-line drugs(capreomycin, kanamycin and amikacin), in addition to isoniazid and rifampicin. This makes XDR-TB treatmentextremely complicated, if not impossible, in general treatment. In a 2006 XDR-TB outbreak in KwaZulu-Natal,South Africa, 52 of 53 people who contracted the disease died within months, It is estimated that 70% of XDR-TBpatients die within a month of diagnosis. The most recent drug-resistance surveillance data issued by the WHOestimates that an average of roughly 5 percent of Multi-drug resistant tuberculosis (MDR-TB) cases are XDR-TB.Estimating the incidence of XDR-TB is extremely difficult because most laboratories are ill-equipped to detect anddiagnose. To avoid the emergence of more resistant strains that may lead to almost untreatable disease, we mustfocus our efforts on the right management of drug resistance tuberculosis. |
