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The Effectiveness of the Diagnosis of Endothelial Dysfunction and its Pharmacological Correction with a Focus on Angiotensin Converting Enzyme Inhibitors |
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| รหัสดีโอไอ | |
| Creator | Ilona Viktorovna Bestaeva , Murad Aslambekovich Khasanov , Gulshan Anver Babirova , Zakhra Zaurovna Askerova , Lora Khasanbekovna Dzotsieva , Alina Yurievna Maslova |
| Title | The Effectiveness of the Diagnosis of Endothelial Dysfunction and its Pharmacological Correction with a Focus on Angiotensin Converting Enzyme Inhibitors |
| Contributor | - |
| Publisher | TuEngr Group |
| Publication Year | 2565 |
| Journal Title | International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies |
| Journal Vol. | 13 |
| Journal No. | 8 |
| Page no. | 13A8L: 1-8 |
| Keyword | Arterial hypertension, Endothelial dysfunction, Angiotensin-converting enzyme inhibitors, Vascular endothelium, Nitrogen monoxide, Oxidative stress. |
| URL Website | http://TuEngr.com/V13-8.html |
| Website title | ITJEMAST V13(8) 2022 @ TuEngr.com |
| ISSN | 2228-9860 |
| Abstract | The vascular endothelial lining is a kind of unique endocrine system, which is located around the perimeter of absolutely all organs of the vascular system. Why endocrine: in modern cardiology, the main importance in the occurrence and development of almost all pathologies is assigned to neurohormonal breakdowns in the form of an imbalance between vasoconstrictors and vasodilators. On one side of the hormonal balance are neurohormones that cause vasoconstriction, remodeling and antidiuresis. These are components of the renin-angiotensin aldosterone and sympathoadrenal systems, endothelin, vasopressin. They are counteracted by hormones with vasodilating and diuretic effects that block remodeling processes, the main of which are nitrogen monoxide, as well as natriuretic peptides, the kallikreinkinin system and prostacyclin. Endotheliocytes play the role of an effective buffer between the blood flow and the tissues of the body, performing a number of regulatory functions, producing a large variety of biologically active substances. The strategic location of the endothelium allows it to be sensitive to the slightest changes in the hemodynamic system and not only in it. Thus, the vascular endothelium plays a key role in maintaining homeostasis. This review article presents the main pathogenetic aspects of endothelial dysfunction, methods of diagnosis and its correction. |
