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Efficacy and safety of herbal medicines for prevention hepatotoxicity from anti-tuberculosis drug (anti-TB-DILI): A systematic review and meta-analysis of randomized controlled trials |
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| รหัสดีโอไอ | |
| Creator | Pattaraporn Akkahadsee |
| Title | Efficacy and safety of herbal medicines for prevention hepatotoxicity from anti-tuberculosis drug (anti-TB-DILI): A systematic review and meta-analysis of randomized controlled trials |
| Contributor | Ratree Sawangjit, Panumart Phumart |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2566 |
| Journal Title | Isan Journal of Pharmaceutical Sciences |
| Journal Vol. | 19 |
| Journal No. | 1 |
| Page no. | 57-70 |
| Keyword | Hepatotoxicity, anti-TB drug, herbal medicine, Curcuma longa |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal of Pharmaceutical Sciences, IJPS |
| ISSN | 19050852 |
| Abstract | Anti-tuberculosis drug-induced liver injury (anti-TB-DILI) is the most common adverse events necessitating therapy interruption. There is at present no standard regimen to prevent anti-TB-DILI. Therefore we performed a systematic review and meta-analysis to determine the efficacy and safety of herbal medicines for preventing anti-tuberculosis drug-induced liver injury (anti-TB-DILI) among tuberculosis patients. Methods: We searched published reports through the electronic databases including Pubmed, Embase, Scopus, Embase, Cochrane Central Register of Controlled Trials and databases in Thailand from inception to March 2022. The researchers selected randomized trials with a control group on the efficacy of herbs used for prevention of TB drug-induced liver injury among tuberculosis patients. The effect sizes were pooled using the random-effects model and expressed as relative risk (RR) or mean difference (MD) with 95% confidence intervals (CI). This study is registered with PROSPERO, number CRD42022353910. Result: The search identified a total of 2,507 related studies but 8 studies with 1,774 TB patients were included in this study. Time to follow-up duration were 2 to 24 weeks. The meta-analysis showed that Turmeric plus Tinospora cordifolia significantly reduced the incidence of anti-TB-DILI compared with placebo (RR: 0.05 (95%CI:0.01 to 0.19). While poly-herbal product and silymarin significantly reduced Aspartate aminotransferase (AST) (WMD = -21.80 (-27.56, -16.04) and 5.21 (-9.92, -0.51), respectively) Conclusion, Turmeric plus Tinospora cordifolia may provides the benefit with safe for preventing anti-TB DILI in TB patients, whereas poly-herbal product and Silymarin may provide benefit on reduction of AST which is a key enzyme to determine hepatotoxicity. |
