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Physical and Chemical Stability of Glycerin Formulations Containing Extracts from Albizia myriophylla and Cha-Em-Thang Song |
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| รหัสดีโอไอ | |
| Creator | Puwadet Ritdet |
| Title | Physical and Chemical Stability of Glycerin Formulations Containing Extracts from Albizia myriophylla and Cha-Em-Thang Song |
| Contributor | Rattanawadee Masthong, Surasak Limsuwan, Oraphan Sakulkeo, Nantiya Joycharat |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2563 |
| Journal Title | Isan Journal ofPharmaceutical Sciences |
| Journal Vol. | 16 |
| Journal No. | 2 |
| Page no. | 45-56 |
| Keyword | Cha-Em-Thang Song, Glycerin, Stability, Traditional Thai Medicine |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal ofPharmaceutical Sciences, IJPS |
| ISSN | 19050852 |
| Abstract | Cha-Em-Thai (Albizia myriophylla Benth; Fabaceae) is a medicinal plant that is used to treat inflammatory-related diseases in folk medicine of various countries. In traditional Thai medicine, "Cha-Em-Thang Song", which consists of A. myriophylla and Glycyrrhiza glabra (Fabaceae), is constituted in Thai herbal formula used for the treatment of oral ulcers. The objective of this research was to study on physical and chemical stability of glycerin formulations containing extracts from A. myriophylla and Cha-Em-Thang Song. Methods: Two forms of glycerin formulations, including those containing extracts from A. myriophylla and Cha-Em-Thang Song were prepared. The physical (appearance, layer separation, sediment, color, pH, and viscosity) and chemical (TLC chromatogram and total phenolic content) stabilities of the prepared formulations were determined under heating-cooling cycle (5-45 ?C; 6 cycles) and real-time storage condition (30 ?C for 30 days), compared to those of the formulations on Day 0. Results: After the product was prepared (day 0), the results showed that glycerin formulations of A. myriophylla and Cha-Em-Thang Song have yellowish brown to red, smooth texture, no layer separation, no precipitation and sediment on edge of the container, viscosity ranging from 117.33 to 145.00 cP, pH 7.00, similar total phenolic contents, and ?-sitosterol in TLC chromatograms. The results of heating-cooling test demonstrated that both formulations have faded in colors, no layer separation, suspended sediment, precipitation and sediment on edge of the container, viscosity ranging from 108.00-121.00 cP, pH ranging from 7.00-7.01, total phenolic content ranging from 4.2-5.4 mg GAE/g extract, and ?-sitosterol in TLC chromatograms. After storage condition at 30 ? C for 30 days, the results revealed that both formulations have darken in colors, no layer separation, suspended sediment, precipitation and sediment on edge of the container, viscosity ranging from 81.33-100.17 cP, pH ranging from 7.00-7.01, total phenolic content ranging from 4.2-5.0 mg GAE/g extract, and ?-sitosterol in TLC chromatograms. Based on our findings, both glycerin formulations tend to have good physical and chemical stability with slight changes in color and sediment. Conclusion: Both prepared glycerin formulations had similar physical and chemical stabilities under heating-cooling test and storage condition at 30 ?C for 30 days. These results may be used as information for further development of more stable herbal products containing extracts from Albizia myriophylla and Cha-Em-Thang Song for the remedy of oral inflammatory diseases. |
