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CYP4A : Roles, Expression, and Clinical Impacts |
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| รหัสดีโอไอ | |
| Creator | Nathaphon Kuncharoenwirat |
| Title | CYP4A : Roles, Expression, and Clinical Impacts |
| Contributor | Kanokwan Jarukamjorn |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2562 |
| Journal Title | Isan Journal of Pharmaceutical Sciences |
| Journal Vol. | 15 |
| Journal No. | 2 |
| Page no. | 17-30 |
| Keyword | Cytochrome P450 4A, w-hydroxylation, arachidonic acid, 20-hydroxyeicosatetraenoic acid, peroxisome proliferator activated receptor a, CYP4A polymorphism |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal ofPharmaceutical Sciences; IJPS |
| ISSN | 19050852 |
| Abstract | Cytochrome P450 4A enzyme (CYP4A) plays an important role in w/w-1 hydroxylation of fatty acids (FA). w-Hydroxylation of arachidonic acid via CYP4A results in 20-hydroxyeicosatetraenoic acid (20-HETE), which is a potent vasoconstriction agent associated to cardiovascular disease. Hence, regulation of CYP4A expression is considered as a factor involved in the condition. Regarding the studies in rodents, regulatory expression of CYP4A is mediated by peroxisome proliferator activated receptor a (PPARa). After binding to a ligand, e.g. fibrates, plasticizers, and pesticides, the PPARa-ligand complex is formed and translocated to form a heterodimer with retinoid X receptor (RXR) in nucleus. The heterodimer bind with the specific base-sequences on peroxisome proliferator response element (PPRE) of CYP4A, followed by transcription of the gene. Nevertheless, this phenomenon does not occurred in human CYP4A, though human and rodents show very high percentage of base-sequences similarity. Regulatory mechanism of human CYP4A is presently unclear. Due to clinical reports, there is a relationship between polymorphism of human CYP4A and chronic diseases, e.g. diabetes retinopathy, abnormal lipid profile, and essential hypertension, etc. Therefore, this review focuses on significant role, expression, clinical impacts of CYP4A to be fundamental information for the study on regulation of human CYP4A expression and a guide to predict complications of chronic diseases associated CYP4A polymorphism. |
