|
Assessment of the Efficacy of Emulgel Contained Miracle Fruit Extract for Skin Care |
|---|---|
| รหัสดีโอไอ | |
| Creator | pornpun laovachirasuwan |
| Title | Assessment of the Efficacy of Emulgel Contained Miracle Fruit Extract for Skin Care |
| Contributor | Phapangkorn Knamsangkot, Thanchanok kadkasem, Preeyanuch Sangcomphoom, Methin Phadungkit |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2561 |
| Journal Title | Isan Journal of Pharmaceutical Sciences |
| Journal Vol. | 14 |
| Journal No. | 3 |
| Page no. | 165-173 |
| Keyword | miracle fruit extract, emulgel, Cutometer MPA 580 |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal ofPharmaceutical Sciences, IJPS |
| ISSN | 19050852 |
| Abstract | Synsepalum dulcificum (miracle fruit, miracle berry) belongs to the SAPOTACEAE. From the literature review found that miracle fruit had antioxidant and anti-tyrosinase activities. The objectives of this study were to formulate the emulgel of miracle fruit extract which was a good properties and stability. The effectives of emulgel of miracle fruit extract with healthy volunteers were also investigated. Materials and methods: The miracle fruits were extracted with 95% ethanol by soxhlet extraction apparatus and evaporated. The emulgel of miracle fruit extract were formulated. The properties and stability by freeze thaw cycle of the emulgel were observed. The irritation, complacency, and efficiency test on healthy volunteers (n=30) by Cutometer MPA 580 such as Colorimeter, Corneometer, Tewameter, and Glossymeter were evaluated. Results: The miracle fruit extract was sticky and dark brown color. The percentage of yield was 36.93 %w/w. The emulgel were consisted of emulsion base and gel base in 1:7 of ratio. The physical appearance was light brown emulgel. The physical appearance, pH, and viscosity of emulgel were not significantly changed after freeze thaw cycle (P>0.05). The complacency of formulation on color and texture was moderately satisfied. However, the odor, skin penetration, and overall liking was rated as very good. None of the volunteers had skin irritation, or allergic to the test product. Therefore, the emulgel of miracle fruit have the efficiency to promote the healthy skin. The transepidermal waterloss was reduced. The brightening, moisture, and glossy of skin were increased. The healthy skin was observed after 4 weeks of emulgel continuously application (P < 0.05). Conclusions: The emulgel have a good trend to increase the healthy skin. The emulgel of miracle fruit was higher potency for skin care than emulgel base at the 4th weeks (P > 0.05). However, it is not clear how effective the skin is due to the miracle fruit extract. Therefore, it is suggested to study the use of emulgel for continuous more than 4 weeks to confirm the efficacy of emulgel of miracle fruit extract. |
