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A Review on the Mechanism of Oxidative Stress-Induction in the Liver by Xenobiotics |
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| รหัสดีโอไอ | |
| Creator | Yollada Sriset |
| Title | A Review on the Mechanism of Oxidative Stress-Induction in the Liver by Xenobiotics |
| Contributor | Waranya Chatuphonprasert, Kanokwan Jarukamjorn |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2561 |
| Journal Title | Isan Journal of Pharmaceutical Sciences |
| Journal Vol. | 14 |
| Journal No. | 1 |
| Page no. | 1-12 |
| Keyword | Oxidative stress, ethanol, sodium selenite, tert-butyl hydroperoxide, liver |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal ofPharmaceutical Sciences, IJPS |
| ISSN | 19050852 |
| Abstract | Oxidative stress results from an imbalance between antioxidant and free radical oxidants, especially reactive oxygen species (ROS). ROS are highly reactive molecules that can be generated by endogenous and exogenous factors. Liver is the target organ for ROS generation because it mainly exposes to various substances in metabolism and biotransformation to result in ROS production. Thus, xenobiotic exposure is the most external factor which causes ROS formation. The understanding of oxidative stress mechanism is essential in order to support the notion that ROS relate with illnesses. Ethanol, sodium selenite, and tert-butyl hydroperoxide (TBHP) are commonly used as oxidative stressors. The previous studies revealed the potentials of these compounds to induce oxidative stress both in vitro and in vivo. The oxidative stress-mechanism of ethanol, sodium selenite, and TBHP associate with metabolic processes in the liver. Ethanol is metabolized via alcohol dehydrogenase, cytochrome P450 2E1 (CYP2E1), and catalase to produce ROS and acetaldehyde. Superoxide anion is produced by the metabolism of sodium selenite via glutathione system while the metabolism of TBHP via CYP2E1 and glutathione peroxidaseglutathione reductase system generates peroxyl and alkoxyl including tert-butylalcohol. Furthermore, the prior studies suggested that TBHP was a strong oxidative stressor because of using the least concentration and time for induction of oxidative stress both in vitro and in vivo studies. Therefore, the knowledge of oxidative stress mechanism and specific properties of compounds for ROS generation are worth for development of an appropriate oxidative stress model for a study on the impact of an antioxidant to investigate its effect on the mechanism behind oxidative stress. |
