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Induction of Colitis in Experimental Animals : A Review |
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| รหัสดีโอไอ | |
| Creator | Nitima Tatiya-aphiradee |
| Title | Induction of Colitis in Experimental Animals : A Review |
| Contributor | Waranya Chatuphonprasert, Kanokwan Jarukamjorn |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2560 |
| Journal Title | Isan Journal of Pharmaceutical Sciences |
| Journal Vol. | 13 |
| Journal No. | 4 |
| Page no. | 1-10 |
| Keyword | Colitis, Inflammatory bowel disease, Animal model |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal ofPharmaceutical Sciences, IJPS |
| ISSN | 19050852 |
| Abstract | Inflammatory bowel disease (IBD) is a complex multifactorial disease that involves all or part of digestive tract consists of two forms; Crohn's disease (CD) and ulcerative colitis (UC). However, the etiology of the disease remains elusive and unclear. Hence, an experimental animal model becomes to be recognized as a valuable method and indispensable tool to provide a wide range of options for investigating the mechanism and disease pathophysiology and also facilitate the study on preclinical design to target specific components. The objective of this review is to summarize models for induction of colitis in experimental animals. These models are categorized by the principles and causes of colitis induction, in which these are divided into 4 categories, i.e., chemical induced colitis model, bacterial induced colitis model, adoptive cell transferred colitis model, and transgenic or gene-knockout colitis model. Thus, the optimal model is individual consideration depended on the aim of the study to obtain the informative and applicable data. |
