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Development of Famotodine Floatinf Tablets |
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| รหัสดีโอไอ | |
| Creator | Chawalinee Asawahame |
| Title | Development of Famotodine Floatinf Tablets |
| Contributor | - |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2553 |
| Journal Title | Isan Journal ofPharmaceutical Sciences |
| Journal Vol. | 6 |
| Journal No. | 2 |
| Page no. | 74-83 |
| Keyword | famotidine, floating tablet |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal ofPharmaceutical Sciences, IJPS |
| ISSN | 19050852 |
| Abstract | The purpose of this research was to develop famotidine floating tablet by study the influence of differentamount of hydroxypropyl methylcellulose 4000 (20 % and 30%), type of fillers (spray dried lactoseand microcrystalline cellulose PH102) and compression force (2000 pound and 4000 pound) on its releaserate and physical property. The floating tablets of famotidine were prepared by direct compression method.The prepared tablets were evaluated for physical properties, floating properties (floating lag time, floating time and matrix integrity) and drug release properties. The results shows that tablet composition and mechanical strength have the greatest influence on the floating properties and drug release. Famotidine tablets contains 30% of HPMC 4000 was found to achieve optimum floating properties and the drug release from those tablets was sufficiently sustained (more than 8 hours). Increase in the compression force increased the floating lag time. It was found that using difference filler in this study showed the difference in the mechanism of drug release. |
