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Immunomodulating Activity of Chikusetsusaponin IVa from Alternanthera philoxeroides |
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| รหัสดีโอไอ | |
| Creator | Ariya Rattanathongkom |
| Title | Immunomodulating Activity of Chikusetsusaponin IVa from Alternanthera philoxeroides |
| Contributor | Bung-orn Sripanidkulchai, Tripetch Kanchanapoom |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2551 |
| Journal Title | Isan Journal ofPharmaceutical Sciences |
| Journal Vol. | 4 |
| Journal No. | 2 |
| Page no. | 113-120 |
| Keyword | Alternanthera philoxeroides, chikusetsusaponin IVa, splenocyte |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal ofPharmaceutical Sciences, IJPS |
| ISSN | 19050852 |
| Abstract | Alternanthera philoxeroides has been used as antipyretic, dressing for wounds and ulcers in Thai traditional medicine. The present study aims to investigate the immunomodulating activity of this plant by using splenocyte proliferation test. The results showed that methanol (MeOH) extract, diethyl ether (EtโO) and n-butanol (n-BuOH) fractions of A. philoxeroides were not cytotoxic to host cells up to the concentration tested (200 ยตg/ml). For immunomodulating study, MeOH extract, EtโO and n-BuOH fractions suppressed splenocyte proliferation. EtโO fraction at a concentration of 50 ยตg/ml significantly suppressed splenocyte proliferation (p < 0.05). Whereas chikusetsusaponin IVa increased splenocyte proliferation in dose-dependent manner and at a concentration of 25 ยตg/ml the compound significantly increased splenocyte proliferation (p < 0.05). |
