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BRCA1 and TP53 mutations in ovarian cancer: Molecular genetic insights and updated situations in Thailand |
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| รหัสดีโอไอ | |
| Creator | Sumana Dakeng, Sureerut Porntadavity, Pimpicha Patmasiriwat |
| Title | BRCA1 and TP53 mutations in ovarian cancer: Molecular genetic insights and updated situations in Thailand |
| Contributor | Sumana Dakeng, Sureerut Porntadavity, Pimpicha Patmasiriwat |
| Publisher | Genetics Society of Thailand |
| Publication Year | 2561 |
| Journal Title | Genomics and Genetics |
| Journal Vol. | 11 |
| Journal No. | 3 |
| Page no. | 26-34 |
| Keyword | ovarian cancer, BRCA1, TP53, mutations, Thailand |
| URL Website | https://www.tci-thaijo.org/index.php/gst/issue/view/12588 |
| Website title | https://www.tci-thaijo.org/index.php/gst/article/view/126035 |
| ISSN | 24655198 |
| Abstract | Ovarian cancer is the sixth most common cancer among Thai women. It is the most lethal gynecologic cancer worldwide. The incident rate increases in women over 45 years old. Several genetic factors linked to ovarian cancer have been identified. Previous reports showed that women with deleterious mutations in BRCA1 gene have a high risk of developing ovarian tumors during their lifetime. TP53 mutation is also recognized as one of genetic factors associated with ovarian cancer. Around 50% of ovarian cancer patients contain various mutations in the TP53 gene resulting in the overexpression of the mutated proteins. Additionally, mutations of BRCA1 together with TP53 were found in the most aggressive subtype high-grade serous ovarian cancer (HGSOC). The prevalence of BRCA1 and TP53 mutations in breast and ovarian cancers has been reported in many population groups. However, the mutation types seem to be different depending on ethnicity. In Thailand, the significance of both BRCA1 and TP53 gene mutations on ovarian cancer initiation and progression has not been completely elucidated. This review points out the incidence and association between BRCA1 as well as TP53 mutations and ovarian cancer. Cumulative data obtained from Thai population are shown. The knowledge may help for improvement of genetic screening, prognosis and treatment selection for ovarian cancers in our country in the near future. |
