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Evaluation of Potential Genotoxic Effects Induced by Chlorothalonil in Human Lymphocytes in Vitro |
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| รหัสดีโอไอ | |
| Creator | Awad A Algarni |
| Title | Evaluation of Potential Genotoxic Effects Induced by Chlorothalonil in Human Lymphocytes in Vitro |
| Publisher | Thai Society of Higher Education Institutes on Environment |
| Publication Year | 2564 |
| Journal Title | EnvironmentAsia |
| Journal Vol. | 14 |
| Journal No. | 3 |
| Page no. | 117-123 |
| Keyword | Chlorothalonil, Genotoxicity, Chromosome aberrations, Mitotic index, Sister chromatid exchange, Human peripheral lymphocytes |
| URL Website | http://www.tshe.org/ea/index.html |
| Website title | EnvironmentAsia |
| ISSN | 1906-1714 |
| Abstract | Chlorothalonil is a widespread non-systemic fungicide used for the control of fungal infections in agriculture of vegetables and fruits. Due to the widespread use of chlorothalonil, chlorothalonil has been detected in all environmental systems, which poses potential risks to human health. The genotoxic effects of the fungicide Chlorothalonil were analyzed in cultured human peripheral lymphocytes by use of cytogenetic parameters including chromosomal aberrations, sister chromatid exchange and mitotic index. Blood samples were obtained from two healthy Non-smoker volunteers (aged 25 to 26 year old). Human lymphocytes were treated with four different concentrations of Chlorothalonil (1, 5, 20, and 50 ?g/mL). The results of this study showed that Chlorothalonil significantly increased the frequency of chromosomal aberrations and sister chromatid exchange compared to the negative control. Moreover, chlorothalonil significantly decreased the mitotic value at all concentrations. Current findings show that Chlorothalonil is clastogenic and induces in vitro DNA damage in human lymphocytes. |
