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Demographic and clinical factors associated with change of drug regimen due to adverse drug reactions among new tuberculosis patients in the upper north and upper northeast of Thailand: A secondary data analysis from a routine regional TB reporting system |
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| รหัสดีโอไอ | |
| Creator | 1. Surachet Arunothong 2. Choopong Sangsawang 3. Panithee Thammawijaya 4. Srisongchai Rattanajiamrangsri 5. Sudjai Hoothummakul |
| Title | Demographic and clinical factors associated with change of drug regimen due to adverse drug reactions among new tuberculosis patients in the upper north and upper northeast of Thailand: A secondary data analysis from a routine regional TB reporting system |
| Publisher | Faculty of Medicine |
| Publication Year | 2558 |
| Journal Title | Chiang Mai Medical Journal |
| Journal Vol. | 54 |
| Journal No. | 3 |
| Page no. | 109-119 |
| Keyword | Tuberculosis,change of drug regimen,adverse drug reactions,the upper north of Thailand,the upper northeast of ThailandThailand, the upper northeast of Thailand |
| ISSN | 0125-5983 |
| Abstract | Objective This study aimed to identify demographic and clinical factors associated with change of the anti-TB drug regimen due to adverse drug reactions (ADRs) among new tuberculosis (TB) patients in the upper north and upper northeast regions of Thailand.Methods A cross-sectional study was conducted among new Prevention and Control region 10 (the upper north area) from 1 Oct 2008 to 30 Sep 2013 and region 6 (the upper northeast area) from 1 Oct 2012 to 30 Sep 2013. Demographic and clinical data and the status of changing drug regimen were extracted from the (TBCM) database. Multivariate logistic regression was used to analyze the association between change of drug regimen and the determinants.Results Records were analyzed of 26,444 and 5,982 new northeast areas of Thailand, respectivelydue to ADRs was 2.01%. Multivariate analysis of the study population revealed factors signi associated with this change, including old age, and being registered in the upper north area, female, human immunode? ciency virus (HIV) co-infected, an anti-retroviral drug useruser, and having co-morbiditiesConclusions Liver disease was a factor commonly associated with change of drug regimen due to ADRs among new TB patients in the two regional areas. Further clinical trials are needed to discover effective interventions during treatment for the prevention of disease. Other associated factors should be monitored properlyTB patients in each area. |
