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Impact of G-6-PD, SLCO1B1 and UGT1A1 variants on severity of neonatal hyperbilirubinemia in Northeastern Thailand |
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| รหัสดีโอไอ | |
| Creator | Supphanan Subin |
| Title | Impact of G-6-PD, SLCO1B1 and UGT1A1 variants on severity of neonatal hyperbilirubinemia in Northeastern Thailand |
| Contributor | Noppmats Khemtonglang, Pakaphan Kiatchoosakun, Kanokwan Sanchaisuriya, Kriengkrai Kitcharoen, Suttiphan Kitcharoen |
| Publisher | Faculty of Associated Medical Sciences, Khon Kaen University, Thailand |
| Publication Year | 2563 |
| Journal Title | Archives of Allied Health Sciences |
| Journal Vol. | 32 |
| Journal No. | 2 |
| Page no. | 27-35 |
| Keyword | G-6-PD, SLCO1B1, UGT1A1, Northeastern Thailand, Neonatal hyperbilirubinemia |
| URL Website | https://he01.tci-thaijo.org/index.php/ams/about |
| Website title | Archives of Allied Health Sciences (Arch AHS) |
| ISSN | 2730-1990 |
| Abstract | Neonatal hyperbilirubinemia is a common complication in Thailand. The polymorphisms of SLCO1B1 (encoding solute carrier organic anion transporter 1B1) and UGT1A1 (uridine diphosphate glucuronosyltransferase 1A1) as well as G-6-PD mutationsassociated with glucose-6-phosphate dehydrogenase deficiency have been reported as genetic risk factors for this condition. This study investigated the association between these genetic variations with severity of neonatal hyperbilirubinemia in northeastern Thai newborns. Neonates (n = 204) with hyperbilirubinemiawere analyzed for common G-6-PD mutations and polymorphisms of SLCO1B1 c.388G>A, SLCO1B1 c.521T>C and UGT1A1 g.-3279T>G using restriction fragment length polymorphism-PCR assay. G-6-PD mutations are significant genetic risk factors for severe neonatal hyperbilirubinemia indicated by significantly higher peak total serum bilirubin (coefficient = 0.93, 95% CI: 0.22-1.64, p-value = 0.011), longer duration of phototherapy (coefficient = 14.45, 95% CI: 6.92-21.99, p-value = 0.0001), early (โค48 hours) onset of hyperbilirubinemia (OR = 2.29, 95% CI: 1.22-4.31, p-value= 0.010) and more hospital readmission (OR = 4.13, 95% CI: 1.09-15.67, p-value = 0.037). SLCO1B1 c.388G>A, SLCO1B1 c.521T>C and UGT1A1g.-3279T>G polymorphisms were present in northeastern Thai neonates with allele frequencies similar to those of other Asian populations,but they were not associated with severity of neonatal hyperbilirubinemia. These findings indicate that if genetic factors impacting on neonatal hyperbilirubinemia are to be more fully understood, a larger cohort study of these genetic variations and other pertinent genes involved in neonatal bilirubin will be needed |
