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Hydrogel-forming microneedles with epigallocatechin gallate and 4-(hydroxymethyl)-phenylboronic acid for antibacterial wound healing and drug release |
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| รหัสดีโอไอ | |
| Creator | Duangkanok Tanangteerapong |
| Title | Hydrogel-forming microneedles with epigallocatechin gallate and 4-(hydroxymethyl)-phenylboronic acid for antibacterial wound healing and drug release |
| Contributor | Naritsara Suwatsrisakun, Jindarat Ekprasert |
| Publisher | Khon Kaen University, Thailand |
| Publication Year | 2569 |
| Journal Title | Asia-Pacific Journal of Science and Technology |
| Journal Vol. | 31 |
| Journal No. | 1 |
| Page no. | 6 (11 pages) |
| Keyword | EGCG, Microneedle, Crosslinking, Drug release |
| URL Website | https://apst.kku.ac.th/ |
| Website title | https://apst.kku.ac.th/hydrogel-forming-microneedles-with-epigallocatechin-gallate-and-4-hydroxymethyl-phenylboronic-acid-for-antibacterial-wound-healing-and-drug-release/ |
| ISSN | 2539-6293 |
| Abstract | Wounds in diabetic patients represent a major therapeutic challenge, necessitating advanced treatment strategies with sustained drug delivery and infection control. This research introduces a hydrogel-based microneedle dressing incorporating epigallocatechin gallate (EGCG) and 4-(hydroxymethyl)-phenylboronic acid (HPBA), focusing on the crosslinking interactions that govern their structural, mechanical, and functional performance. Among the tested formulations, the hydrogel containing EGCG and HPBA in a 1:1 ratio exhibited the greatest swelling ability, which was likely due to its efficient capacity to retain water. Meanwhile, the HPBA-only hydrogel showed the lowest swelling ability due to its dense polymer network. The 1:1 formulation also exhibited superior mechanical strength and flexibility, enabled by efficient crosslinking that enhanced structural integrity. Drug release studies revealed that the EGCG-HPBA (1:2) hydrogel allowed for rapid initial drug release, while the 1:1 formulation provided a slower, sustained release profile, making it more suitable for controlled drug delivery. Moreover, EGCG demonstrated significant bactericidal activity toward E. coli and S. aureus, and this activity was retained upon integration with HPBA. The results demonstrate that the EGCG-HPBA (1:1) hydrogel microneedle system is a promising multifunctional dressing for chronic wound management, combining mechanical resilience, controlled drug release, and antibacterial efficacy. |
