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TLR4, BTN1A1, and Pit-1 polymorphisms and their associations with the estimated breeding values of growth traits of Brahman cattle in Thailand |
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| รหัสดีโอไอ | |
| Creator | Monchai Duangjinda |
| Title | TLR4, BTN1A1, and Pit-1 polymorphisms and their associations with the estimated breeding values of growth traits of Brahman cattle in Thailand |
| Contributor | Jiraporn Pancharoen, Somporn Chockcharoen, Yupin Phasuk, Wuttigrai Boonkum |
| Publisher | Asia-Pacific Journal of Science and Technology |
| Publication Year | 2567 |
| Journal Title | Asia-Pacific Journal of Science and Technology |
| Journal Vol. | 29 |
| Journal No. | 1 |
| Page no. | 8 |
| Keyword | Thai Brahman cattle, TLR4, BTN1A1, Pit-1, Growth traits, EBV |
| URL Website | https://so01.tci-thaijo.org/index.php/APST |
| Website title | https://so01.tci-thaijo.org/index.php/APST/article/view/267033 |
| ISSN | 2539-6293 |
| Abstract | The molecular analysis of genes is considered an acceptable tool for accelerating the genetic improvement of production performance in cattle. Single nucleotide polymorphisms (SNPs) in Toll-like receptor 4 (TLR4) and Butyrophilin subfamily 1 member A1 (BTN1A1) genes are related to immunity and may affect all aspects of cattle production. Pituitary-specific positive transcription factor 1 (Pit-1) is related to expression of the growth hormone-releasing factor gene. There were used in this study to examine the associations with estimated breeding values (EBVs) of growth traits [birth weight (BW), weaning weight (WW), and yearling weight (YW)] of Brahman cattle. Two hundred sixty-five cattle blood samples were obtained for DNA extraction, and gene polymorphisms were analyzed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The TLR4 gene was associated with the EBV of WW, which was significantly higher with the AB genotype than with the AA genotype (p โค0.05) in cattle. This gene was associated with the EBV of YW, which was significantly higher in the cattle with the AB genotype than in those with the AA genotype (p โค0.05). Cattle with the genotypes AA and AB had a higher (p โค0.05) EBV of WW than cattle with the BB genotype of the BTN1A1 gene, which was also significant. The Pit-1 gene was associated with the EBV of BW, which was significantly lower in cattle with the genotype BB than in those with the genotype AA (p โค0.05). The possibility of selecting growth traits using these three genetic markers is therefore interesting. |
