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Cancer Research Advance in CKLF-like MARVEL Transmembrane Domain Containing Member Family (Review) |
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| รหัสดีโอไอ | |
| Creator | Jia Lu, Qian-Qian Wu, Ya-Bo Zhou, Kai-Hua Zhang, Bing-Xin Pang, Liang Li, Nan Sun, Heng-Shu Wang, Song Zhang, Wen-Jian Li, Wei Zheng, Wei Liu |
| Title | Cancer Research Advance in CKLF-like MARVEL Transmembrane Domain Containing Member Family (Review) |
| Publisher | APJCP |
| Publication Year | 2559 |
| Journal Title | Asian Pacific Journal of Cancer Prevention |
| Journal Vol. | 17 |
| Journal No. | 6 |
| Page no. | 2741-2744 |
| Keyword | CMTM family, gene, chemokine-like factor, tumor |
| Abstract | CKLF-like MARVEL transmembrane domain-containing family (CMTM) is a novel family of genes first reported at international level by Peking University Human Disease Gene Research Center. The gene products are between chemokines and the transmembrane-4 superfamily. Loaceted in several human chromosomes, CMTMs, which are unregulated in kinds of tumors, are potential tumor suppressor genes consisting of CKLF and CMTM1 to CMTM8. CMTMs play important roles in immune, male reproductive and hematopoietic systems. Also, it has been approved that CMTM family has strong connection with diseases of autoimmunity, haematopoietic system and haematopoietic system. The in-depth study in recent years found the close relation between CMTMs and umorigenesis, tumor development and metastasis. CMTM family has a significant clinical value in diagnosis and treatment to the diseases linking to tumor and immune system. |
