|
Decreased Serum Monocyte Chemoattractant Protein-1 in Salivary Gland Tumor Patients |
|---|---|
| รหัสดีโอไอ | |
| Creator | Maryam Mardani |
| Title | Decreased Serum Monocyte Chemoattractant Protein-1 in Salivary Gland Tumor Patients |
| Publisher | APJCP |
| Publication Year | 2559 |
| Journal Title | Asian Pacific Journal of Cancer Prevention |
| Journal Vol. | 17 |
| Journal No. | 7 |
| Page no. | 3601-3604 |
| Keyword | Salivary gland tumor , MCP-1 , pleomorphic adenoma , adenoid cystic carcinoma , mucoepidermoid |
| Abstract | Background: The monocyte chemoattractant protein-1 (MCP-1/CCL2) is a potent chemoattractant for natural killer cells, monocytes, and memory T lymphocytes. However, any role in the genesis of salivary gland tumors (SGT) is unknown. To assess the diagnostic relevance of chemokines in SGT, MCP-1 levels in the serum of patients were investigated in association with tumor progression and clinical aggressiveness. Materials and Methods: Using an ELISA kit, we assessed and compared the circulating levels of MCP-1 in blood serum of 70 SGT patients with 44 healthy control samples. Results: The results of this study showed that the concentration of MCP-1 was significantly lower in patients with benign (463.8ฑ158.5pg/ml, P=0.033) and malignant (454.8ฑ190.4pg/ ml, P=0.007) SGT than in healthy subjects (645.7ฑ338.9). No significant difference in mean serum levels of MCP-1 was observed between the benign and malignant group (p=0.9). While MCP-1 levels were lower in patients with an advanced clinical stage, advanced tumor size, higher tumor grade, or lymph node involvement, but the mean MCP-1 level between groups showed no statistically significant difference (p>0.05). Conclusions: MCP-1 levels in the serum of patients with SGT were decreased, indicating that this might a good marker for discriminating patients with SGT from healthy people. However, no clear-cut relationship was detected between MCP-1 levels and clinicopathologic factors, and MCP-1 is not a good marker for evaluating tumor dissemination. |
