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Maximum Diameter of Intracranial Metastatic Lesions as a Prognostic Factor in Patients Following Whole Brain Radiotherapy |
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| รหัสดีโอไอ | |
| Creator | Komsan Thamronganantasakul, |
| Title | Maximum Diameter of Intracranial Metastatic Lesions as a Prognostic Factor in Patients Following Whole Brain Radiotherapy |
| Publisher | APJCP |
| Publication Year | 2559 |
| Journal Title | Asian Pacific Journal of Cancer Prevention |
| Journal Vol. | 17 |
| Journal No. | 7 |
| Page no. | 3495-3498 |
| Keyword | Brain metastasis , whole brain radiotherapy , intracranial lesion maximum diameter , prognostic factor |
| Abstract | Purpose: To evaluate whetehr maximum diameter of intracranial metastatic lesions may be a prognostic factor in intracranial metastatic patients receiving whole brain radiotherapy. Materials and Methods: The records of 114 cases who between January 2005 and December 2007 were retrospectively reviewed. There were 85 who met the inclusion criteria. Results: In these 85, the one-year overall survival rate was 16.5% and the median survival time was 125 days. Median survival in relation to recursive partitioning analysis (RPA) classes I, II and III were 216, 133 and 85 days. Log-rank tests of initial prognostic factors were significant for RPA classifications, Karnofsky Performance Status(KPS), maximum diameters of intracranial metastatic lesions and presence of necrotic centers. The median survivals with a maximum diameter of the largest intracranial metastatic lesion <3cm and _3cm were 162 days and 104 days (p=0.027). Multivariate analysis also showed a statistical significance for maximum diameter of intracranial metastatic lesions and presence of necrotic centers. Conclusions: Maximum diameters of intracranial metastatic lesions could be used as a prognostic factor in patients receiving whole brain radiotherapy and may help radiation oncologists to make decisions on treatment plans. |
