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Computational approaches to predict human protein targets of Spirulina Compounds for the Treatment of Systemic Lupus Erythematosus |
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| รหัสดีโอไอ | |
| Title | Computational approaches to predict human protein targets of Spirulina Compounds for the Treatment of Systemic Lupus Erythematosus |
| Creator | Marasri Ruengjitchatchawalya |
| Contributor | Han Ping, Teeraphan Laomettachit |
| Publisher | The Thai Society for Biotechnology |
| Publication Year | 2562 |
| Keyword | Bioactive Compounds, Spirulina, Systemic Lupus Erythematosus, Random Walk with Restart, Drug Target Prediction |
| Abstract | Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by autoantigen exposure, autoantibody production, chronic inflammation and tissue damage. The patients can be affected by SLE in heterogeneous severity ranging from skin and joint pain to heart attack, neuro-disorder, and even death. Unfortunately, there is no specific treatment for SLE at present. Therefore, it is necessary to identify more potential targets. From a previous study, potential bioactive compounds from Arthrospira Platensis C1 were proposed to target SLE proteins. These compounds are natural supplement and not associated with toxicity. In the present study, we utilized multiple computational approaches with the aim to identify potential SLE-associated protein targets of those Spirulina compounds. First, 471 known SLE genes were used as an input to construct an SLE association protein network. A random walk with restart algorithm was then applied to the network to prioritize proteins that are highly associated with the disease, resulting in 44 protein candidates. The 44 candidates were then BLASTPed against SLE protein targets of Spirulina compounds previously reported. Based on the concept that targets with similar sequences tend to bind to the same compounds, we predicted eight SLE proteins as a target of three Spirulina compounds. This prediction was then preliminarily validated by molecular docking technique. Our results propose phycocyanobilin, a highly available compound in Spirulina, and other compounds as potential therapeutic agents that target SLE proteins, including LYN, LCK, FYN and EGFR. |
| Language | EN |
| URL Website | http://tsb2019.com/ |
| Website title | The 31st Annual Meeting of the Thai Society for Biotechnology and International Conference (TSB 2019) |
