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NEUROBLASTOMA CELL-LINE TOXICITY DUE TO INCREASED ALZHEIMER'S-RELATED PROTEINS AND CELL DEATH SUBSEQUENT TO HIGH-DOSE PALMITIC ACID EXPOSURE |
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| รหัสดีโอไอ | |
| Title | NEUROBLASTOMA CELL-LINE TOXICITY DUE TO INCREASED ALZHEIMER'S-RELATED PROTEINS AND CELL DEATH SUBSEQUENT TO HIGH-DOSE PALMITIC ACID EXPOSURE |
| Creator | PRASONG SRIHANAM |
| Contributor | KUMFU SIRINART, CHATTIPAKORN NIPON, CHATTIPAKORN C. SIRIPORN |
| Publisher | Faculty of Technology, Mahasarakham University |
| Publication Year | 2563 |
| Keyword | Palmitic acid, Alzheimer's disease, Neuronal cell, Amyloid beta, Tau |
| Abstract | Obesity caused by high-fat diet (HFD) consumption is one of the risk factors for the development of Alzheimer's disease (AD). Previous studies have reported that saturated fatty acids from an HFD, particularly palmitic acid (PA), promotes Alzheimer's pathologies, neuroinflammation and cognitive impairment. The pathological hallmarks of AD are characterized by the accumulation of amyloid-? (A?) peptides and phosphorylated Tau (pTau) proteins. However, the expression of A? peptides, and Tau proteins levels, as well as the viability of cell in neuronal cells induced by PA remain unclear. Therefore, this study aims to determine the effect of high concentrations of PA on cell viability and Alzheimer's-related proteins of neuronal cells. In this study, SH-SY5Y was used as a neuronal cell model in order to investigate the effect of PA at a concentration of 400 and 800 ?M. The results showed that neuronal cell exposed to PA at doses of 400 and 800 ?M for 24 and 48 hours had decreased cell viability in a dose-dependent manner. In addition, receiving PA for 48 hours induced A? peptides and p-Tau proteins production. Our study suggests that high concentration of PA exposure can lead to increased risk of the development of Alzheimer's pathologies and neuronal cell death. |
| Language | EN |
| URL Website | https://techno2.msu.ac.th/icofab/welcome/ |
| Website title | The 7th International Conference on Food Agriculture & Biotechnology(ICoFAB 2020) |
