|
ANTIMALARIAL COMPOUNDS FROM DENDROBIUM VENUSTUM |
|---|---|
| รหัสดีโอไอ | |
| Title | ANTIMALARIAL COMPOUNDS FROM DENDROBIUM VENUSTUM |
| Creator | Prapapun Sukphan |
| Contributor | Boonchoo Sritularak, Kittisak Likhitwitayawuid |
| Publisher | Chulalongkorn University |
| Publication Year | 2556 |
| Keyword | Dendrobium, Antibacterial agents, Malaria, หวาย (กล้วยไม้), สารต้านแบคทีเรีย, มาลาเรีย |
| Abstract | Bioactivity guided isolation of a methanol extract prepared from Dendrobium venustum to the isolation of two bibenzyls (gigantol, batatasin III) and five phenanthrenes (pherenanthrene, lusi, phoyunanin C, E). Their structures were determinated by analysis of spectroscopic methods and bioactivity. Antimalaria activity of gigantol, batatasin III, densifloral B, phoyunnanin C and E have IC50 values of 0.012, 0.039, 0.001, 0.006, 0.001 µM respectively. Dihydroartemisinin and mefloquine were used as positive controls with IC50 values of 0.0018, and 0.0314 µM respectively. In addition, they were evaluated for cytotoxicity assay (dermal skin fibroblast cell lines). Gigantol, batatasin III, and densifloral B were not cytotoxic to dermal skin fibroblast cell lines . |
| URL Website | cuir.car.chula.ac.th |
