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Halogenation of n-heteroaromatic hydroxy compounds with pph3/halogenating agent |
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| รหัสดีโอไอ | |
| Title | Halogenation of n-heteroaromatic hydroxy compounds with pph3/halogenating agent |
| Creator | Woranun Kijrungphaiboon |
| Contributor | warinthorn chavasiri |
| Publisher | Chulalongkorn University |
| Publication Year | 2554 |
| Keyword | Complex compounds, Heterogeneous catalysis, การเร่งปฏิกิริยาวิวิธพันธุ์, สารประกอบเชิงซ้อน |
| Abstract | Two new methodologies utilizing conventional heating and microwave (MW) heating for halogenation of N-heteroaromatic hydroxy compounds using PPh₃ and halogenating agent have been developed. The optimal conditions for the synthesis of N-heteroaromatic halides including type of halogenating agent, amount of reagents, reaction time and solvent were explored. In the case of conventional heating, Cl₃CCN or CBr4 in combination with PPh₃ approved to be a highly reactive reagent for the conversion of N-heteroaromatic hydroxy compounds to the corresponding halides in refluxing toluene for 4 h. On the other hand, Cl₃CCN, Cl₃CCOCCl₃ and CBr₄ with PPh3 could convert N-heteroaromatic hydroxy compounds and coumarin derivatives to desired halides in high yields at 150°C for 20 min under MW irradiation. |
| URL Website | cuir.car.chula.ac.th |
