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Microwave-assisted sonogashira-type coupling of terminal alkynes and aryl boronic acid |
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| รหัสดีโอไอ | |
| Title | Microwave-assisted sonogashira-type coupling of terminal alkynes and aryl boronic acid |
| Creator | Suttikiat Puechmongkol |
| Contributor | Worawan Bhanthumnavin, Boonchoat Paosawatyanyong |
| Publisher | Chulalongkorn University |
| Publication Year | 2554 |
| Keyword | Microwaves, Microwave ovens, Catalysis, ไมโครเวฟ, เตาไมโครเวฟ, การเร่งปฏิกิริยา |
| Abstract | A microwave reactor for chemical synthesis have been designed and constructed. Microwave irradiation provided a selective heating to the reaction mixture. The main advantage of use microwave-assisted is reaction acceleration, yield improvement, and safe. An easy, rapid methodology for microwave-assisted Sonogashira-type coupling reactions of arylboronic acids with electron-deficient terminal alkynes in absence of ligand under ambient atmosphere is described. The reactions used low loading palladium-atalyzed in silver-assisted system, K2CO3 as base, and THF as solvent to afford the corresponding product in moderate-high yield in 20 min with only 100 Watt microwave power. Thus, it represents a simple and alternative method for conventional heating. |
| URL Website | cuir.car.chula.ac.th |
