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Formulation development and Evaluation of Hydrophobic Base Containing Herbal extracts for Oral Ulcers |
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| รหัสดีโอไอ | |
| Title | Formulation development and Evaluation of Hydrophobic Base Containing Herbal extracts for Oral Ulcers |
| Creator | Chanchit Leesatijakul |
| Contributor | Kraisri Umprayn |
| Publisher | Chulalongkorn University |
| Publication Year | 2549 |
| Keyword | Mouth -- Ulcers -- Treatment, Plant extracts, Polyethylene, ปาก -- แผลเปื่อย -- การรักษา, สารสกัดจากพืช, โพลิเอทิลีน |
| Abstract | This research study tended to develop hydrophobic base with suitable gelling agents containing mangostin and/or asiaticoside for the relief of oral lichen planus and apthous ulcer. Hydrophobic base with good physical appearance was prepared from melting process of plyethylene polymer (PE) and mineral oil at about 80 degree Celsius. PE polymer in mineral oil was found to precipitate as small crystallites surrounded by long fibrous amorphous filaments which intermesh and produce a sponge-like structure resulting in a three dimentional lattice responsible for stable gel structure. Among various percentages of PE in this study, it was found that the appropriate amount of PE polymer in hydroiphobic base was 4.5 percent. From rheogram at various temperatures, hydrophobic base exhibits psuedoplastic behavior. Activation energy calculated from modified Arrhenius’s equation was about 12.45 kj/mol. Gelatin, xanthan gum, pectin, sodium evaluated for suitable gelling agent in hydrophobic base. Chitosan salts prepared by spray-drying process with suitable conditions were fine yellowish powder with round shape. Among these gelling agents mixed with hydrophobic base, SCMC, pectin, chitosan glutamate molecular weight 227000, butylated hydroxytoluene (BHT) and active ingredient (either mangostin or asiaticoside_ was suitable. From photoxidation study the result revealed that the percent contents of both mangostin and asiaticoside in formulation using BHT as antioxidant were slightly changed with in acceptablelimit. In addition, after 4 months of stability study at 30 degree Celsius the percent contents of mangostin and asiaticoside in formulation seem to be unchanged at various storage time intervals |
| ISBN | 9741427395 |
| URL Website | cuir.car.chula.ac.th |
