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Percutaneous absorption of UV filters |
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| รหัสดีโอไอ | |
| Title | Percutaneous absorption of UV filters |
| Creator | Patcharawalai Klinubol |
| Contributor | Supason Wanichwecharungruang, Pravit Asawanonda |
| Publisher | Chulalongkorn University |
| Publication Year | 2549 |
| Keyword | Chemicals, Skin absorption, Ultraviolet radiation, Sunscreens (Cosmetics), สารเคมี, สารกันแดด, รังสีเหนือม่วง, การดูดซึมของผิวหนัง |
| Abstract | In this work, percutaneous absorption of UV filters through baby mice skins (Mus musculus Linn) and volunteer human skins were studied by Franz diffusion cell and Suction Blister techniques. The results showed very good correlation of the absorption result between baby mice skin and human skin. Among octyl methoxycinnamate, butyl methoxy dibenzoylmethane, 4-methyl benzylidene camphor, Eusolex UV pear OMC, di(2-ethylhexyl)-2,4,5-trimethoxybenzalmalonate, 2-ethylthexy1-2, 4-5-trimethoxycinnamate, dihexyl-2,4,5-trimethoxybenzalmalonate, diethyl-2,4,5-trimethoxy benzalmalonate, poly-(3-hydroxy-propoxy) cinnamic acid, poly-(6-hydroxy-hexyloxy)cinnamicacid, poly-(11-hydroxy-undecyloxy)cinnamic acid, poly penta ethylene glycol cinnamate, poly(p-propoxycinnamate)-co-(p-undecyloxycinnamate), poly [vinyl-2,4,5-trimethoxycinnamate(vinyl alcohol)]copolymer, 4-methoxycinamoylphthaoyl irradiated chitosan, only octyl methoxycinnamate and butyl methoxy dibenzoylmethane gave significant transdermal penetration results. The two newly developed UV fiters di-(2-ethylhexyl)-2,4,5-trimethoxybenzalmalonate and 2-ethylhexyl-2,4,5-trimethoxycinnamate showed no trans-epidermal penetration. |
| URL Website | cuir.car.chula.ac.th |
