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Prevalence and Risk Factors of Chloroquine and Hydroxychloroquine Retinopathy |
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| รหัสดีโอไอ | |
| Creator | 1. Sireedhorn Kurathong 2. Kornwipa Hemarat 3. Seerung Noonpradej 4. Siriporn Manavathongchai |
| Title | Prevalence and Risk Factors of Chloroquine and Hydroxychloroquine Retinopathy |
| Publisher | Text and Journal Publication |
| Publication Year | 2564 |
| Journal Title | Vajira Medical Journal |
| Journal Vol. | 65 |
| Journal No. | Suppl Nov |
| Page no. | S1-14 |
| Keyword | prevalence, risk factor, chloroquine retinopathy, hydroxychloroquine retinopathy |
| URL Website | https://tci-thaijo.org/index.php/VMED |
| Website title | Vajira Medical Journal (วชิรเวชสาร) |
| ISSN | 0125-1252 |
| Abstract | Objective: To evaluate the prevalence and risk factors of chloroquine and hydroxychloroquine retinopathy. Methods: Retrospective cohort study was conducted at Vajira hospital. Medical records of autoimmune patients who received chloroquine and hydroxychloroquine from January 2017 to December 2019 were reviewed. Results: Of the 177 enrolled patients, 19 patients developed retinopathy. The prevalence of chloroquine and hydroxychloroquine retinopathy was 10.7%. 17 patients had the pericentral pattern of retinal change, whereas only 2 patients had the classic parafoveal distribution of retinal damage. Factors associated with retinopathy were duration of chloroquine treatment (p=0.009), cumulative dose of chloroquine (p=0.009) and cumulative dose of chloroquine with hydroxychloroquine (p=0.015). After using multivariate analysis, duration of chloroquine treatment (adjusted OR=1.01; 95%CI 1.00-1.02, p=0.01) and liver disease (adjusted OR=23.72; 95%CI 1.25-448.68, p=0.035) were significant. Conclusions: The prevalence of chloroquine and hydroxychloroquine retinopathy was 10.7%. Factors associated with retinopathy were duration of chloroquine treatment and liver disease. Factors that may associated with retinopathy were cumulative dose of chloroquine, cumulative dose of chloroquine with hydroxychloroquine. |
