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Nocturnal Intraocular Pressure in Primary Open Angle Glaucoma and Obstructive Sleep Apnea Patient with CPAP Treatment |
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| รหัสดีโอไอ | |
| Creator | 1. Polporn Apiwattanasawee 2. Thansook Kasemsap 3. Pradtana Hirunpattarawong |
| Title | Nocturnal Intraocular Pressure in Primary Open Angle Glaucoma and Obstructive Sleep Apnea Patient with CPAP Treatment |
| Publisher | Text and Journal Publication |
| Publication Year | 2561 |
| Journal Title | Vajira Medical Journal |
| Journal Vol. | 62 |
| Journal No. | 6 |
| Page no. | 423-30 |
| Keyword | Obstructive sleep apnea (OSA), Primary open-angle glaucoma (POAG), Intraocular pressure (IOP), Continuous positive airway pressure (CPAP) |
| URL Website | https://tci-thaijo.org/index.php/VMED |
| Website title | Vajira Medical Journal (วชิรเวชสาร) |
| ISSN | 0125-1252 |
| Abstract | Objective: To compare nocturnal intraocular pressure (IOP) in primary open-angle glaucoma (POAG) and obstructive sleep apnea (OSA) patient with and without continuous positive airway pressure (CPAP) machine Methods: Prospective control study in 16 eyes of patients who diagnosed POAG and OSA. First night patients obtained sleep study to confirm diagnosis of OSA and measured intraocular pressure (IOP) every 2 hours. Second night patients also obtained sleep study additional CPAP pressure adjust for treatment OSA and measured IOP every 2 hours in the same procedure. Results: Eight patients (sixteen eyes) were enrolled for the study. Mean age was 60.6 ? 4.53 years, 75 % were male, mean BMI was 26.64 ? 1.84 kg/m2 and mean apnea-hypopnea index (AHI) was 37.42 ? 15.62 /hour. Average IOP in the first night (no CPAP use) sleep study were differ from average IOP in the second night (CPAP use) at each time (22.00, 24.00, 02.00, 04.00 and 06.00) non significant ( p value = 0.35). Average IOP in the first night were 19.06 ? 0.9 mm Hg with peak IOP 19.87 mm Hg at 06.00. Average IOP in the second night were 17.26 ? 1.48 with peak IOP 19 mm Hg at 04.00. Conclusions: The first line treatment option for moderate or severe obstructive sleep apnea is CPAP. Beside of elimination apnea, hypopnea or respiratory effort related arousal (RERA) events, it improve sleep quality, desaturation during sleep and may reduce IOP in POAG or delay glaucomatous progression. However further study for CPAP use and long term outcome of glaucoma change such as retinal fiber layer thickness visual field change should be beneficial. |
