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Clinical Characteristics and outcome of HIV-positive and HIV-negative related with Diffuse Large B-cell lymphoma at Faculty of Medicine Vajira hospital, Navamindradhiraj University |
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| รหัสดีโอไอ | |
| Creator | 1. Naphat Wutilertcharoenwong 2. Oraphan Kongpanvijit |
| Title | Clinical Characteristics and outcome of HIV-positive and HIV-negative related with Diffuse Large B-cell lymphoma at Faculty of Medicine Vajira hospital, Navamindradhiraj University |
| Publisher | Text and Journal Publication |
| Publication Year | 2561 |
| Journal Title | Vajira Medical Journal |
| Journal Vol. | 62 |
| Journal No. | 1 |
| Keyword | - |
| URL Website | https://tci-thaijo.org/index.php/VMED |
| Website title | Vajira Medical Journal (วชิรเวชสาร) |
| ISSN | 0125-1252 |
| Abstract | Objective: The aim of this study is to identify the differences of clinical characteristics, laboratory investigations and clinical outcome after treatment with CHOP or R-CHOP between HIV-positive and HIV-negative related with diffuse large B-cell lymphoma in Faculty of Medicine Vajira Hospital. Methods: This study is a retrospective cohort study of all patients diagnosed with diffuse large B-cell lymphoma at the Department of Internal Medicine, Faculty of Medicine, Vajira Hospital between January 1, 2010 and December 31, 2016. All patients were treated with either CHOP or R-CHOP for at least 4 cycles. The inclusion criteria are being at least 15 years of age, HIV-infected and receiving antiretroviral therapy. The exclusion criteria include the lack of pathological confirmation, the absence of HIV testing results and the lack of laboratory investigation or radiological imaging, such as the computer tomography of the chest, the abdomen and bone marrow study. Results: There were 12 patients with HIV-related diffuse large B-cell lymphoma (DLBCL) (11.1%) and 96 patients with non-HIV related DLBCL (88.9%) . HIV-infected DLBCL patients had a higher mortality rate than non-HIV related DLBCL patients, 4 patients died in the HIV-positive group (33.3%), while 6 patients died in the HIV-negative group (6.2%) (p-value, OR (95% CI) = 0.034, 5.177 (1.132-23.670) ) . The HIV-related DLBCL group was younger and worse prognosis than other group. Moreover, the HIV-positive group usually had advanced stage of lymphoma and elevated LDH. These were the clinical characters that were significant difference between HIV-positive and HIV-negative patients. However, the response rate after chemotherapy was not significant difference when compared between 2 groups. (p-value, OR (95% CI) = 0.777, 0.0825 (0.218-3.128) ) . Conclusion: Patients with HIV-related diffuse large B-cell lymphoma have a higher mortality and more aggressive clinical-biological features than those with non-HIV with diffuse large B-cell lymphoma. However, there is no difference in the clinical response to treatments between the two groups. |
