|
Pharmacokinetics of oxfendazole nanosuspension in sheep |
|---|---|
| รหัสดีโอไอ | |
| Creator | Dongmei Chen |
| Title | Pharmacokinetics of oxfendazole nanosuspension in sheep |
| Contributor | Yuzhu Sun, Xiaofang Wang, Aoxue Zhang, Bao Zhang, Liwei Shao, Yue Liu, Haiting Wang, Wanhe Luo, Shuyu Xie |
| Publisher | Chulalongkorn University |
| Publication Year | 2564 |
| Journal Title | The Thai Journal of Veterinary Medicine |
| Journal Vol. | 51 |
| Journal No. | 1 |
| Page no. | 29 |
| Keyword | Oxfendazole, Nanosuspension, HPLC, Pharmacokinetics |
| URL Website | https://he01.tci-thaijo.org/index.php/tjvm/index |
| Website title | https://he01.tci-thaijo.org/index.php/tjvm/index |
| ISSN | 0125-6491 |
| Abstract | The pharmacokinetics of our previous prepared oxfendazole nanosuspension was studied in sheep to understand its enhancement of bioavailability. Ten sheep were randomly divided into two groups, each of which received a single-dose (5mg/kg) oral oxfendazolenanosuspension and oxfendazolegranules. After intragastric administration,oxfendazole rapidly reached peak concentrations of 11.25 ?g/mL and 5.50 ?g/mLat 5.6 h and 6.6 hin the nanosuspension group and granules group and the concentrations gradually reduced to below the detection limit at 96 h and 72h, respectively. The main pharmacokinetic parameters of oxfendazoleafter administration to the sheep: The Tmax, Cmax, AUClast, MRTlast, T1/2and Ke of in nanosuspension were 5.6 h, 11.26 ?g/mL, 179.22 ?g*h/mL, 17.82 h, 87.22 h and 0.012 1/h, respectively, while the these main pharmacokinetic parameters in the OFZ granules group were 6.6 h, 5.50 ?g/mL, 105.28 ?g*h/mL, 16.55 h, 35.04 h, and 0.020 1/h, respectively. Compared with the granules group, the Cmaxand AUClastof the nanosuspension group were increasedby 2.05 and 1.70 times, respectively, and the Cmaxand AUClastof the total active compound in the nanosuspension group were increased by 1.85 times and 1.71 times, respectively. These results suggest that the oxfendazole suspension might be an effective and promising formulation for use in sheep. |
