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Identification and characterization of a novel protective antigen, SeseC_00396 of Streptococcus equissp. Zooepidemicus |
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| รหัสดีโอไอ | |
| Creator | Yang Wang |
| Title | Identification and characterization of a novel protective antigen, SeseC_00396 of Streptococcus equissp. Zooepidemicus |
| Contributor | Li Yi, Weiping Yang, Jinpeng Li, Shaohui Wang |
| Publisher | Chulalongkorn University |
| Publication Year | 2564 |
| Journal Title | The Thai Journal of Veterinary Medicine |
| Journal Vol. | 51 |
| Journal No. | 2 |
| Page no. | 231 |
| Keyword | Streptococcus equi ssp. Zooepidemicus, Immune protection, Immunogen, Vaccine |
| URL Website | https://he01.tci-thaijo.org/index.php/tjvm/index |
| Website title | https://he01.tci-thaijo.org/index.php/tjvm/index |
| ISSN | 0125-6491 |
| Abstract | Streptococcus equi ssp. zooepidemicus (SEZ) is responsible for a wide variety of infections in many animal species. Studies aimed at developing safe and effective vaccines against SEZ infections are thus of great interest. SeseC_00396 was a novel protein identified in the previous study. In this study, recombinant SeseC_00396of SEZwas expressed and showed a strong immunoreactivity with mini-pig convalescent sera. Studies in mice have revealed thatthe recombinant protein induced a marked antibody response which was associated with protection against SEZ infection. The hyperimmune sera against SeseC_00396 could efficiently kill the bacteria. In addition, it was also found that anti-SeseC_00396 antibodies can significantly inhibit the formation of SEZ biofilm.Data from this study suggests that SeseC_00396 identified in SEZ may represent immunogens of interest for vaccine development. |
