|
Prevalence of Endometrial Cancer in Patients with Endometrioid Intraepithelial Neoplasia Histology |
|---|---|
| รหัสดีโอไอ | |
| Creator | Thanchanok Sompratthana |
| Title | Prevalence of Endometrial Cancer in Patients with Endometrioid Intraepithelial Neoplasia Histology |
| Contributor | Natkrita Pohthipornthawat, Somsook Santibenchakul, Shina Oranratanaphan |
| Publisher | PIMDEE Co., Ltd. |
| Publication Year | 2567 |
| Journal Title | Thai Journal of Obstetrics and Gynaecology |
| Journal Vol. | 32 |
| Journal No. | 5 |
| Page no. | 400-408 |
| Keyword | atypical endometrial hyperplasia, concurrent endometrial cancer, endometrial carcinoma, endometrioid intraepithelial neoplasia (EIN), occult cancer |
| URL Website | https://tci-thaijo.org/index.php/tjog/index |
| Website title | www.tci-thaijo.org |
| ISSN | 2673-0871 |
| Abstract | Objectives: The primary objective was to ascertain the prevalence of concurrent endometrial cancer among patients initially diagnosed with endometrial intraepithelial neoplasia (EIN). The secondary objective was to assess the characteristics and risk factors associated with occult endometrial cancer in EIN patients. Materials and Methods: This retrospective study analyzed cases spanning from 2015 to 2019 of patients diagnosed with EIN through various endometrial biopsy methods, including endometrial sampling, fractional curettage, or hysteroscopic biopsy. Demographic information and histological findings from hysterectomy specimens were collected to determine the prevalence of concurrent endometrial cancer. In the conservative group, patients were categorized as not having concurrent cancer if malignancy was not found in the 12-month follow-up period. Descriptive statistics were employed to evaluate the prevalence of concurrent endometrial cancer in EIN patients, alongside demographic and clinical characteristics. Multivariable logistic regression analysis was utilized to explore the association between demographics and clinical factors with concurrent endometrial cancer. Results: A total of 130 EIN patients were included. The mean age of patients diagnosed with concurrent endometrial cancer was 47.02 (standard deviation (SD) 13.2) years and 52.23 (SD 10.9) years for those without endometrial cancer. The prevalence of concurrent endometrial cancer in EIN patients was 23.1%, (95% confidence interval 16.1 - 31.2). The prevalence of concurrent endometrial cancer in the surgical group was 32.5% and in the conservative group was 8%. All patients diagnosed with concurrent endometrial cancer exhibited uterine-confined disease, with no diagnoses of stage III or IV disease. Conclusion: Approximately one-third to one-fourth of EIN patients diagnosed via endometrial sampling were found to have concurrent endometrial cancer. Notably, all patients diagnosed with concurrent endometrial cancer exhibited uterine-confined disease. We recommend using this data for counseling patients who have EIN in both surgical and conservative cases. |
