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Intravenous Dexamethasone for Preventing Postoperative Nausea and/or Vomiting in Total Abdominal Hysterectomy: A randomized double-blinded, placebo-controlled trial |
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| รหัสดีโอไอ | |
| Creator | Kanyawee Suhongsa |
| Title | Intravenous Dexamethasone for Preventing Postoperative Nausea and/or Vomiting in Total Abdominal Hysterectomy: A randomized double-blinded, placebo-controlled trial |
| Contributor | Jesada Wutitammasuk, Thumwadee Tangsiriwatthana |
| Publisher | PIMDEE Co., Ltd. |
| Publication Year | 2567 |
| Journal Title | Thai Journal of Obstetrics and Gynaecology |
| Journal Vol. | 32 |
| Journal No. | 3 |
| Page no. | 196-204 |
| Keyword | postoperative nausea and vomiting, PONV, dexamethasone, hysterectomy |
| URL Website | https://tci-thaijo.org/index.php/tjog/index |
| Website title | www.tci-thaijo.org |
| ISSN | 2673-0871 |
| Abstract | Objectives: To assess the efficacy of postoperative dexamethasone compared to placebo in reducing the incidence of postoperative nausea and/or vomiting (PONV) in women undergoing benign total abdominal hysterectomy (TAH).Materials and Methods: Participants who were scheduled for TAH with or without adnexal surgery between August 2022 and April 2023 were included. The participants were randomly divided into two groups: the dexamethasone group (n = 43), who received 2 ml (8 mg) of intravenous dexamethasone injection, and the control group (n = 43) received 2 ml of normal saline at 2 hours after surgery.Results: There was no significant difference in the incidence of PONV within 24 hours between the dexamethasone group and control group (32.6% vs 48.8%, relative risk 0.67(95% confidence interval 0.39 to 1.13), p = 0.09). The need for antiemetic drugs was not statistically different between groups (0% vs 9.3%, p = 0.05), and without serious adverse events in both groups. The dexamethasone group experienced a lesser pain score than the control group at 24 hours (4.7 ? 1.5 vs 5.8 ? 2.2, p = 0.01) after surgery. There was no difference in additional analgesic requirements.Conclusion: The administration of 8 mg of intravenous dexamethasone postoperatively did not result in a significant reduction in PONV within the first 24 hours following benign TAH. |
