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Subsequence Pregnancy Outcomes after Treatment of Gestational Trophoblastic Disease in King Chulalongkorn Memorial Hospital |
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| รหัสดีโอไอ | |
| Creator | Sanpoompai Khaoprasert |
| Title | Subsequence Pregnancy Outcomes after Treatment of Gestational Trophoblastic Disease in King Chulalongkorn Memorial Hospital |
| Contributor | Ruangsak Lertkhachonsuk |
| Publisher | PIMDEE Co., Ltd. |
| Publication Year | 2562 |
| Journal Title | Thai Journal of Obstetrics and Gynaecology |
| Journal Vol. | 27 |
| Journal No. | 4 |
| Page no. | 203-209 |
| Keyword | gestational trophoblastic disease, molar pregnancy, subsequent pregnancy, gestational trophoblastic neoplasia |
| URL Website | https://tci-thaijo.org/index.php/tjog/index |
| Website title | www.tci-thaijo.org |
| ISSN | 2673-0871 |
| Abstract | Objectives: To review subsequent pregnancy outcome in gestational trophoblastic disease (GTD) patients at King Chulalongkorn Memorial hospital.Materials and Methods: Retrospective cohort study was done between 2001 and 2015. Women whom diagnosed with gestational trophoblastic disease at King Chulalongkorn Memorial Hospital, Bangkok, Thailand were recruited. Data were reviewed by medical record and telephone interview regarding subsequent pregnancy outcome and clinical data. Results: There were 147 GTD patients enrolled during study period, 82 pregnant women were observed. Final diagnosis was complete hydatidiform mole 40 cases (48.78%), partial hydatidiform mole 11 cases (13.41%), postmolar gestational trophoblastic neoplasia 28 cases (34.15%) and non-molar gestational trophoblastic neoplasia 3 cases (3.66%). Mean age at diagnosis was 25.04 years (range 14-36 years). Median interval from remission to subsequent pregnancy was 36 months (range 3-132 months). There were 80 from 82 cases spontaneous pregnancy. Three patients (3.66 %) was pregnant before 1 year. For first subsequent pregnancy outcomes, 71 cases (86.66%) were term live birth, 3 cases (3.66%) were preterm birth and 8 cases (9.76%) were spontaneous abortion. There was no significant difference in pregnancy outcomes between patients who received chemotherapy and who did not receive chemotherapy treatment. Similarly, patients who received single agent chemotherapy and multi-agent chemotherapy had no significant difference in pregnancy outcomes. Conclusion: Around 86% of subsequent pregnancy after GTD remission were term live birth. Subsequent pregnancy outcomes after GTD were not significantly different between patients with hydatidiform mole and gestational trophoblastic neoplasia. |
