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Adjuvant Chemotherapy for Malignant Ovarian Germ Cell Tumors in Pregnancy |
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| รหัสดีโอไอ | |
| Creator | Jitti Hanprasertpong |
| Title | Adjuvant Chemotherapy for Malignant Ovarian Germ Cell Tumors in Pregnancy |
| Contributor | Kriengsak Dhanaworavibul, Thanasak Sueblinvong |
| Publisher | PIMDEE Co., Ltd. |
| Publication Year | 2562 |
| Journal Title | Thai Journal of Obstetrics and Gynaecology |
| Journal Vol. | 27 |
| Journal No. | 4 |
| Page no. | 176-179 |
| Keyword | malignant ovarian germ cell tumor, ovarian cancer, pregnancy, management, chemotherapy |
| URL Website | https://tci-thaijo.org/index.php/tjog/index |
| Website title | www.tci-thaijo.org |
| ISSN | 2673-0871 |
| Abstract | Malignant ovarian germ cell tumors (MOGCTs) are uncommon in pregnancy, and therefore few gynecologic oncologists obtain expertise in this area. Management of MOGCTs in pregnancy is complicated and complex, requiring a multidisciplinary team in a specialized center. Fertility-sparing surgery is the first choice treatment of MOGCTs, while adjuvant chemotherapy is reserved for high risk cases. The indications for adjuvant chemotherapy after surgery are similar to those for non-pregnant women. Due to the low incidence and insufficient published data, the decision concerning adjuvant chemotherapy is based on case reports or small retrospective cohort studies. Following is a brief review of current knowledge concerning the MOGCTs in pregnancy and its management, especially, adjuvant chemotherapy. includes total abdominal hysterectomy and bilateral salpingo-oophorectomy with staging procedures. However, conservative management with progestin therapy may be considered in selected patients for fertility preservation. Candidates for fertility-sparing treatment are women with early stage, well differentiated endometrioid adenocarcinoma without myometrial invasion. Oncologic and fertility outcomes of patients treated with conservative management are limited. Therefore, close surveillance is needed during conservative management. Definitive treatment should be performed after completion of childbearing. |
