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Spot Urine Albumin to Creatinine Ratio versus Urine Proteinto Creatinine Ratio for the Diagnosis of Proteinuria inPregnancy |
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| รหัสดีโอไอ | |
| Creator | Paroon Sanoonrat |
| Title | Spot Urine Albumin to Creatinine Ratio versus Urine Proteinto Creatinine Ratio for the Diagnosis of Proteinuria inPregnancy |
| Publisher | PIMDEE Co., Ltd. |
| Publication Year | 2560 |
| Journal Title | Thai Journal of Obstetrics and Gynaecology |
| Journal Vol. | 25 |
| Journal No. | 4 |
| Page no. | 249 |
| Keyword | preeclampsia, urine albumin to creatinine ratio, urine protein to creatinine ratio, proteinuria |
| ISSN | 0857-6084 |
| Abstract | Objectives: To evaluate the correlation of the spot urine albumin to creatinine ratio (UACR) and theurine protein to creatinine ratio (UPCR) with 24-hour urine protein (UP-24) collection and toexplore the diagnostic performances of these parameters for detecting signifiant proteinuriain pregnancyMaterials and Methods: This cross-sectional study was conducted on pregnant women at gestationalages 20-41 weeks who had clinically suspected proteinuria and were prospectively enrolledfrom November 2015 to April 2016. Random urine samples for UACR, UPCR and 24-hour urinecollection for protein and creatinine were examined.Results: A total of 115 pregnant women were evaluated. Using UP-24 as the reference standard,signifiant proteinuria was identifid in 39 cases (33.9%). UACR had a higher level of correlationthan UPCR with UP-24 (r = 0.884 and 0.834, respectively). The areas under the receivercharacteristics curves (ROC-AUC) of UACR and UPCR were 96.6% (95%CI; 93.8-99.9) and94.5% (95%CI; 90.4-98.6), respectively. The diagnostic threshold of UACR for signifiantproteinuria was 42 mg/g. (94.9% sensitivity and 86.8% specifiity), whereas the UPCR cutoffvalue was 0.26, (87.2% sensitivity and 90.8% specifiity). Predicted UP-24 using spot UACRadjusted by maternal age had the highest ROC-AUC of 97.4% (95%CI; 95.1-99.6), with asensitivity of 94.9% and a specifiity of 90.8%.Conclusion: Spot UACR showed better correlation with UP-24 than UPCR. Spot UACR adjusted formaternal age, yielded a good diagnostic performance that was not associated with the time ofurine collection and underlying diseases. |
