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Prevention of Postpartum Hemorrhage with Oxytocin versusErgometrine plus Oxytocin in the Third Stage of Labor |
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| รหัสดีโอไอ | |
| Creator | Thitipun Nuamsiri, M.D. |
| Title | Prevention of Postpartum Hemorrhage with Oxytocin versusErgometrine plus Oxytocin in the Third Stage of Labor |
| Publisher | PIMDEE Co., Ltd. |
| Publication Year | 2559 |
| Journal Title | Thai Journal of Obstetrics and Gynaecology |
| Journal Vol. | 24 |
| Journal No. | 2 |
| Page no. | 97-103 |
| Keyword | Blood loss, ergometrine, oxytocin, prevention, adverse effects |
| ISSN | 0857-6084 |
| Abstract | Objective: To evaluate the effect of the addition of intravenous ergometrine to a standard oxytocininfusion on the blood loss during vaginal delivery.Study design: Prospective, double-blinded, randomized controlled trial.Materials and methods: Three hundred and twenty-three women were randomized to receive infusionof either ergometrine 0.2 mg plus oxytocin 20 IU or oxytocin 20 IU, diluted in 1,000 ml of 5%D/N/2,immediately after delivery of the baby. The primary outcome was the estimated blood loss. Thesecondary outcomes included PPH, changes in hemoglobin level, the use of additionaluterotonics, need for blood transfusion and adverse effects.Results: The estimated postpartum blood loss was similar in the oxytocinergometrine andoxytocin groups (145 ml versus 150 ml, p=0.979). None of the women in the oxytocinergometrine group had PPH while one woman (0.6%) in the oxytocin group encountered thiscomplication (p=0.498). There was no signifiant difference between both groups in terms ofchanges in hemoglobin level, use of additional uterotonics and need for blood transfusion.Hypertension was signifiantly more common in the oxytocinergometrine group than in theoxytocin group (6.2% VS 0%, p<0.001).Conclusions: There was no difference in postpartum blood loss during vaginal delivery betweenoxytocinergometrine and oxytocin groups. Hypertension was frequently found in the oxytocinergometrine group. However, other adverse effects were not signifiantly different betweenboth groups. |
