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Comparison of Preterm Delivery Rates between HIV-infected Pregnant Women Receiving Highly Active Antiretroviral Therapy (HAART) Containing Protease Inhibitors (PIs) and HIV-infected Pregnant Women Receiving Zidovudine Monotherapy |
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| รหัสดีโอไอ | |
| Creator | Bongkot Chakornbandit |
| Title | Comparison of Preterm Delivery Rates between HIV-infected Pregnant Women Receiving Highly Active Antiretroviral Therapy (HAART) Containing Protease Inhibitors (PIs) and HIV-infected Pregnant Women Receiving Zidovudine Monotherapy |
| Contributor | Fuanglada Tongprasert |
| Publisher | PIMDEE Co., Ltd. |
| Publication Year | 2558 |
| Journal Title | Thai Journal of Obstetrics and Gynaecology |
| Journal Vol. | 23 |
| Journal No. | 2 |
| Page no. | 68-75 |
| Keyword | HIV, HAART, zidovudine, preterm delivery, protease inhibitors |
| URL Website | https://tci-thaijo.org/index.php/tjog/index |
| Website title | www.tci-thaijo.org |
| ISSN | 0857-6084 |
| Abstract | Objective:To compare the preterm delivery rates between pregnant women receiving HAART containing protease inhibitors (HAART-PIs) and zidovudine monotherapy (ZDVm) during pregnancy.Materials and Methods: A retrospective study was conducted in antiretroviral-na?ve HIV-infected pregnant women who received antiretroviral drugs during pregnancy at least 4 weeks and delivered in Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Thailand between January 2002 and December 2013. Preterm delivery rates were compared between HAART-PIs and ZDVm groups.Results: Of the 166 pregnant women who received antiretroviral drugs, 24 (14.5%) pregnant women delivered before 37 completed weeks. The incidence of preterm delivery was higher in the HAART-PIs group (82 cases) than in the ZDVm group (84 cases), but the difference was not significant (18.3% vs. 10.7%, p = 0.17). Conclusion: The almost twofold incidence of preterm delivery rate was observed in those pregnancy women who received HAART-PIs; however, it was not significantly different from the rate among those who received ZDVm. |
