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ยีนฮีโมโกลบินคอนสแตนท์สปริงในคนเวียดนาม (Hemoglobin Constant Spring Gene in Vietnamese) |
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| รหัสดีโอไอ | |
| Creator | วิทยา จอมอุย |
| Title | ยีนฮีโมโกลบินคอนสแตนท์สปริงในคนเวียดนาม (Hemoglobin Constant Spring Gene in Vietnamese) |
| Publisher | Genetics Society of Thailand |
| Publication Year | 2556 |
| Journal Title | Thai Journal of Genetics |
| Journal Vol. | S.1 |
| Journal No. | S1 (Special Issue 1) |
| Page no. | 396 |
| Keyword | Hemoglobin Constant Spring, ?-globin gene, ?-globin gene haplotype |
| ISSN | 8578664 |
| Abstract | Hemoglobin Constant Spring (Hb Constant Spring; Hb CS) is an abnormal Hb caused by a mutation in termination codon of an ?2-globin gene, TAA -> CAA. This mutation leads to the synthesis of unstable and elongated ?-globin chain. It is found mainly in China and Southeast Asia, but is occasionally found in Europe. ?-globin gene haplotype analysis in Chinese and Mediterranean patients demonstrated different origins of this Hb variant in the two populations. Different ?-globin gene haplotypes associated with Hb CS genes have been documented in Thai, Laos, and Cambodian subjects. It has been found from the study of thalassemia and hemoglobinopathies at the community level in Hue, Vietnam that Hb CS is also very common among Vietnamese. In this study, ?-globin gene haplotype associated with Hb CS in Vietnamese was investigated. Six DNA polymorphisms including (5 |
