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Molecular genetic analysis of CYP2D6 and HLA-B*15:02 in Thai autistic spectrum disorder children: Implication for pharmacogenetics testing and optimization of drug treatments |
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| รหัสดีโอไอ | |
| Creator | 1. Pongwut Suwannarat 2. Montri Chamnanphon 3. Nattawat Ngamsamut 4. Ananya Sinrachatanant 5. Bhunnada Chamkrachchangpada 6. Teerarat Tan-kam 7. Apichaya Puangpetch 8. Chonlaphat Sukasem 9. Penkhae Limsila |
| Title | Molecular genetic analysis of CYP2D6 and HLA-B*15:02 in Thai autistic spectrum disorder children: Implication for pharmacogenetics testing and optimization of drug treatments |
| Publisher | Genetics Society of Thailand |
| Publication Year | 2556 |
| Journal Title | Thai Journal of Genetics |
| Journal Vol. | 6 |
| Journal No. | 1 |
| Page no. | 82 |
| Keyword | autistic spectrum disorders, CYP2D6, HLA-B*15:02, genetic polymorphisms, adverse drug reactions |
| ISSN | 8578664 |
| Abstract | Genetic polymorphisms of CYP2D6 and HLA-B have been associated with efficacy and toxicity variation of various antipsychotic drugs including those for autistic spectrum disorders (ASD). The objective of this study is to investigate and compare allele frequency of CYP2D6 between 79 Thai ASD patients and 154 non-ASD by using microarray technique, and of HLA-B*15:02 between 292 Thai ASDs patients and 627 non-ASDs by using PCR-SSOP based method. The most common allele frequency of CYP2D6*10, *1 and *2 in ASD group were 54.43% (86/158), 22.78% (36/158) and 11.39% (18/158), respectively, and non-ASD were 44.18% (138/308), 26.30% (81/308) and 7.47% (23/308), respectively. The frequencies of HLA-B*15:02 in ASD and non-ASD were 14.72% (43/292) and 14.19% (89/627). There was no statistical significant difference between investigated allele frequency of ASDs and on-ASDs groups. This is the first study of the CYP2D6 and HLA-B*15:02 gene polymorphisms in Thai autistic spectrum disorder patients. This information may be useful to determine the appropriate treatment for Thai autistic spectrum disorders. |
