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Altered Target Sites as a Mechanism of Herbicide Resistance |
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| รหัสดีโอไอ | |
| Creator | Tosapon Pornprom |
| Title | Altered Target Sites as a Mechanism of Herbicide Resistance |
| Publisher | Department of Agriculture |
| Publication Year | 2554 |
| Journal Title | Thai Agricultural Research Journal |
| Journal Vol. | 29 |
| Journal No. | 1 |
| Page no. | 85-100 |
| Keyword | acetolactate synthase (ALS), amino acid synthesis inhibitors, glutamine synthetase (GS), herbicide-resistant crops, point mutation |
| URL Website | http://at.doa.go.th/journal |
| Website title | Thai Agricultural Research Journal |
| ISSN | 0125-8389 |
| Abstract | Development of herbicide-resistant crops has been generated, utilized either conventional and, mutation breeding or genetic engineering approaches, to be resistant to herbicides. Herbicide resistance and be due to target site-based or non-target site-based mechanism. To date, most of the reported herbicide resistance in plants has been linked to target site modification. Mechanisms of target site-based herbicide resistance of the amino acid synthesis inhibitors are reviewed in this paper, with emphasis on the biochemical and molecular basis as acetolactate synthase (ALS) and glutamine synthetase (GS) gene mutation. It is possible that the herbicide-resistant crops show a point mutation as base-pair substitution in the partial of ALS and GS gene. The substitution results in a modified amino acid sequence in the ALS and GS protein as target site-based resistance, and making it less sensitive to inhibitory effect of herbicide. This suggests that the mechanisms of target site-based herbicide resistance may be occurred after the translation or post translation in the ALS and GS gene. Altered target-site mutation in the ALS and GS gene may confer mechanism resistance to amino acid synthesis inhibitors, so that it is technically possible to develop the herbicide resistance trait in many crops. |
