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ORGANOGEL FOR TRANSDERMAL DRUG DELIVERY SYSTEMS |
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| รหัสดีโอไอ | |
| Creator | Paisit Wattanasri, Praneet Opanasopit |
| Title | ORGANOGEL FOR TRANSDERMAL DRUG DELIVERY SYSTEMS |
| Publisher | Faculty of Pharmacy, Silpakorn University |
| Publication Year | 2561 |
| Journal Title | Thai Bulletin of Pharmaceutical Science (TBPS) |
| Journal Vol. | 13 |
| Journal No. | 1(January-June) |
| Page no. | 93-104 |
| Keyword | Organogel, Lecithin, Pluronic, Transdermal drug delivery system |
| URL Website | https://www.tci-thaijo.org/ |
| ISSN | 1686-9540 |
| Abstract | An organogel is a semi-solid system in which an organic liquid phase is immobilized by a three-dimensional network. Organogels can be distinguished from hydrogels by their predominantly organic continuous phase and can be classified into two groups based on their molecular weights of organogelator used: low molecular weight organogelator and polymeric organogelator. These include alanine derivatives lecithin organogel, sorbitan monostearate organogel, and Eudragit? organogel. Furthermore, lecithin organogel has created a lot of interest in pharmaceutical sciences. Lecithin has the ability to form different shapes owing to its amphiphilic structure which can increase the solubility of poorly soluble drugs. Reverse micelles are formed when small amounts of organic solvent are added to lecithin. Cylindrical reverse micelles start growing upon the addition of polar solvents until they intertwine to form a gelling network. Nowadays, lecithin organogel has been developed and is called pluronic lecithin organogel (PLO gel). This has attracted particular interest in the design of transdermal delivery systems to improve drug permeation through the skin and to enhance the stability of formulations. PLO gel is produced when an aqueous solution of Pluronic F127 or Poloxamer 407 is added to the lecithin. PLO gels have been studied for use in the topical delivery of several other hydrophilic and hydrophobic drugs including anesthetics, antiemetics, muscle relaxants, neuropathy drugs, nonsteroidal anti-inflammatory drugs and systemic analgesics. The PLO gel system facilitates the delivery of hydrophilic as well as lipophilic drugs owing to the presence of both oil and aqueous phases within the gel system. |
