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FUNDAMENTAL PRINCIPLE AND APPLICATIONS OF THERMAL ANALYSIS BY DIFFERENTIAL SCANNING CALORIMETRY IN PHARMACEUTICAL SOLID-STATE FORMULATIONS |
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| รหัสดีโอไอ | |
| Creator | Pratchaya Tipduangta, Jakkapan Sirithunyalug |
| Title | FUNDAMENTAL PRINCIPLE AND APPLICATIONS OF THERMAL ANALYSIS BY DIFFERENTIAL SCANNING CALORIMETRY IN PHARMACEUTICAL SOLID-STATE FORMULATIONS |
| Publisher | Silpakorn University |
| Publication Year | 2561 |
| Journal Title | Thai Bulletin of Pharmaceutical Sciences |
| Journal Vol. | 13 |
| Journal No. | 2(July-December) |
| Page no. | 129-143 |
| Keyword | thermal analysis, differential scanning calorimetry, modulated temperature differential scanning calorimetry, solid-state formulation characterization |
| ISSN | 1686-9540 |
| Abstract | Differential scanning calorimetry (DSC) is an important thermal analysis technique which is frequently used in pharmaceuticals, especially in solid-state formulations. The development of Modulated Temperature Differential Scanning Calorimetry (MTDSC) which is an extension of conventional DSC, it employs a non-linear heating rate like a sine wave or seesaw which offers a remarkable advantage of deconvoluting the heat flow signal into reversing heat flow and non-reversing heat flow by using a Fourier transform mathematic deconvolution. MTDSC can separate non-reversible thermal events such as water evaporation or polymer relaxation from reversible thermal events (glass transition temperature). Consequently, it reveals hidden thermal events and improves the resolution of detecting a glass transition temperature. Additionally, this review also focuses on the applications of conventional DSC and MTDSC in pharmaceutical solid-state formulation development including identification of polymorphism of active pharmaceutical ingredients (APIs) and their thermodynamic properties, a study of the crystallization kinetics of APIs, assessment of the interaction between APIs and excipients, and characterization of solid dispersion formulations and the long-term stability of the amorphous drug in the formulations. |
