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CORRELATION BETWEEN THE ANTIMICROBIALS UTILIZATION AND ANTIMICROBIAL- RESISTANCE IN PRASAT NEUROLOGICAL INSTITUTE |
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| รหัสดีโอไอ | |
| Creator | Sermsook La-ongsuwan, Kannika Jaemsak, Tanawadee Chor.soraphong, Vajeethip Kaewbutra, Wasin Laosuebsakhunthai |
| Title | CORRELATION BETWEEN THE ANTIMICROBIALS UTILIZATION AND ANTIMICROBIAL- RESISTANCE IN PRASAT NEUROLOGICAL INSTITUTE |
| Publisher | Faculty of Pharmacy, Silpakorn University |
| Publication Year | 2560 |
| Journal Title | Thai Bulletin of Pharmaceutical Science (TBPS) |
| Journal Vol. | 12 |
| Journal No. | 2 (July-December)2017 |
| Page no. | 21-29 |
| Keyword | antimicrobials, antimicrobial-resistance, Defined Daily Dose (DDD) |
| ISSN | 1686-9540 |
| Abstract | The use of antimicrobial drugs especially carbapenem group at Prasat Neurological Institute has been increasing. The present study is designed to investigate the trend of antimicrobial utilization in the unit of defined daily dose per 1000 patient-bed days. Also, to study the correlation between resistance rate of imipenem/cilastatin and meropenem of multidrug resistance (MDR) and non-MDR of Pseudomonas aeruginosa and Acinetobacter spp. to antimicrobial usage. The data of the antimicrobial use in in-patients was collected in two separated periods, from January 2007 to December 2008 and from January 2011 to December 2016. The total time for data collection was 8 years. Moreover, the information of antibiogram during the data collection period was obtained. The result from this study showed that the use of antimicrobial drugs was significantly increased in three groups which were extended spectrum cephalosporins, carbapenems, and fluoroquinolones groups. This study found the significant correlation in the resistance rate of meropenem in Pseudomonas aeruginosa (MDR) and the increasing of meropenem use (p<0.05). And also, the correlation of the resistance rate of meropenem in Acinetobacter lowffii (non-MDR) and Acinetobacter baumannii (non-MDR) and the increasing of meropenem use was also significant (p<0.01 and p<0.05, respectively). The findings from the present study may be beneficial in planning and developing for the infectious control system in preventing antimicrobial resistance. |
